About this Research Topic
In the past several years, there has been a lot of progress in revealing the mutational landscape of Head and Neck Squamous Cell Carcinoma (HNSCC). For example, a series of hotspot mutational genes such as TP53, CDKN2A, PTEN, PIK3CA, and NOTCH1 were identified and tumors can be now classified based on genomic profiling. In addition, epigenetic profiling revealed non-coding RNAs to play regulatory roles in the pathophysiological progression, including cancer.
Non-coding RNAs including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have been found to be involved in the development and progression of HNSCC and partially associated with locoregional lymph node metastasis, local recurrence and poor, overall survival of HNSCC patients. For instance, the HOTAIR lncRNA acts as a scaffold for histone modification complexes to regulate gene expression through histone tail methylation and its overexpression was correlated with metastasis and poor prognosis in patients with HNSCC.
The aim of the Research Topics is to provide the reader with a comprehensive insight as to how non-coding RNA plays an important role in proliferation, epithelial-mesenchymal transition (EMT), autophagy, drug resistance and tumor microenvironment of Head and Neck Cancer. We welcome Original Research and Review articles describing, but not limited to, the following subtopics:
1. Non-coding RNAs and the proliferation of HNSCC cells
2. Role of non-coding RNAs in the EMT of HNSCC cells.
3. Prognostic and/or predictive factors of non-coding RNAs for patients with HNSCC.
4. Role of non-coding RNAs in the process of autophagy in HNSCC cells
5. Non-coding RNAs mediated drug resistance of patients with HNSCC
6. Non-coding RNAs in the tumor microenvironment of HNSCC
Keywords: Head and neck squamous cell carcinoma, Non-coding RNA, Functional and clinical implications, Early diagnosis, Therapeutic treatment
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