About this Research Topic
Therefore, this Research Topic aims at providing a comprehensive and current overview of preclinical systems that are in development for application as non-viral gene therapies for musculoskeletal disorders, in particular novel approaches that can address delivery efficacy and spatiotemporal control. This includes ex vivo gene therapies that involve in vitro stem cell manipulation as well as approaches for direct in vivo genetic manipulation, limited to non-viral nucleic acid delivery aimed at addressing a clinical problem in the musculoskeletal field. Submissions covering systems to improve efficacy through novel agents or combinations with biomaterials are encouraged as are innovative strategies for advanced spatiotemporal control of delivery and new avenues to endogenous gene regulation/reprogramming.
Keywords: non-viral gene therapy, orthopaedics, preclinical, musculoskeletal disorder
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