About this Research Topic
Epigenetic changes during embryonic development are finely tuned and of paramount importance for correct patterning. A number of chromatin remodelers are involved in pivotal processes and several inborn genetic disorders are associated to genetic variants in genes coding for such proteins. Despite the growing evidences on genetic variants, the cellular and molecular mechanisms remain to be unveiled.
In this context, functional data on in vitro and in vivo models on the impact on cells, tissues, organs and molecular cascades following chromatin remodeling alterations (genetic or drug-induced) would help understanding the embryonic consequences of such disruptions. In the NGS era, whereby new genetic variants causative of birth defects are constantly revealed, the goal of this Research Topic is to gather scientific evidences for the much needed link gene variant-protein function in the specific and unique context of embryonic development.
We welcome articles as Original Research, Review, Methods, and Perspective around developmental processes, birth defects, and in vitro and in vivo studies falling under the following topics:
• Chromatin remodelers genetic variants (or environmentally-induced) functional effects.
• How these alterations affect cells, tissues and organs development.
• How different chromatin remodelers may diverge or converge at the molecular levels.
• Challenges facing the field of genetic disorders related to epigenetic changes in the NGS era.
Keywords: Embryonic Development, Chromatin Remodeling Alterations, Birth Defects
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