About this Research Topic
At the core of the injury, neuronal damage appears to be often irreversible. In contrast, the damage of the tissue surrounding the primary injury locus (secondary damage) could be prevented, thus increasing the survival rates and improving life quality of the patients. Activation of cascades underlying reorganization of the extracellular matrix and stimulation of neuronal plasticity and activity by molecules that play essential roles early in nervous system development is a promising approach for treatment of acute and chronic neurodegeneration. Recent data suggest that various intrinsic transcription factors or extrinsic signals (e.g. growth factors) are involved in remodeling of the nervous tissue after injury. Additionally, extracellular matrix proteases processing receptors, such as cell recognition molecules of the neuronal surface, modulate synaptogenesis and plasticity during recovery. Neuropeptides, purinoreceptors and growth factors are not only essential during nervous system development but also in the process of prevention and recovery after injury where developmental processes are recapitulated.
The aim of this Research Topic is to cover promising and novel research trends on signaling cascades underlying neurodegeneration and regeneration falling under the following points:
• Transcription and neurotrophic factors
• Adult neurogenesis and synaptogenesis
• Extracellular matrix molecules
• Therapeutic approaches
• Extra-, inter- and intra-cellular signaling
We welcome articles as Original Research, Reviews, Mini Reviews, Methods, Clinical Trial, Opinion and General Commentary.
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