Research Topic

Functionalized Organic Fluorescent Materials for Biosensing and Bioimaging

About this Research Topic

The past decades have witnessed extensive biological applications of fluorescence microscopy as a powerful tool for the fluorescent detection of important biological species and processes, for biomedical imaging, and for imaging-guided cancer therapy. This is due to the high selectivity, remarkable sensitivity, fast acquisition, and non-invasive properties of the fluorescent materials used. Among these, small molecule-based fluorescent materials have attracted much interest because of their facile synthesis, easy modification and functionality, and predictable and tunable emissions. On the other hand, organic life systems are highly complex and can be represented by massive biological species. Previous researches have shown that abnormalities and dysfunctions in biological systems are closely associated with many biological activities and even severe diseases. Thus, the development of functionalized organic fluorescent materials for biosensing and bioimaging in live samples is of particular importance.

Recently, remarkable progresses have been achieved in in vitro biological detection and imaging based on organic fluorescent materials. However, organic fluorescent materials with strong two-photon (TP) absorption or near-infrared (NIR) emission for visualization of specific biological species, as well as monitoring in deep tissue and live animals, are still in high demand. In addition, specific visualization of important subcellular biological species, like proteins and related biological processes, remains a great challenge. Therefore, the integration of elegant organic synthesis, photophysical characterization, density functional theory, and molecular docking could help to prepare multiple functionalized organic fluorescent materials with strong TP absorption and NIR emission for in vitro, ex vivo, and in vivo fluorescent detection and imaging.

As such, this Research Topic aims to provide reasonable strategies to synthesize various organic fluorescent materials with versatile functionalities and multicolor emissions, as well as some new insights into their diverse biological applications—especially in biosensing and bioimaging.

In this Research Topic, original research articles, reviews, and perspectives are welcome from multiple disciplines. Research areas may include (but not limited to) the following:

 • Design and synthesis of novel small molecule-based fluorescent materials
 • Development of fluorescent bioprobes based on functionalized organic materials
 • Fluorescent detection of important biological species (ions, small molecules, maromolecules, etc.) and biological processes
 • Two-photon and near-infrared biomedical fluorescence imaging


Keywords: Organic fluorescent materials, Functionality, Biological application, Fluorescent detection, Fluorescence imaging


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The past decades have witnessed extensive biological applications of fluorescence microscopy as a powerful tool for the fluorescent detection of important biological species and processes, for biomedical imaging, and for imaging-guided cancer therapy. This is due to the high selectivity, remarkable sensitivity, fast acquisition, and non-invasive properties of the fluorescent materials used. Among these, small molecule-based fluorescent materials have attracted much interest because of their facile synthesis, easy modification and functionality, and predictable and tunable emissions. On the other hand, organic life systems are highly complex and can be represented by massive biological species. Previous researches have shown that abnormalities and dysfunctions in biological systems are closely associated with many biological activities and even severe diseases. Thus, the development of functionalized organic fluorescent materials for biosensing and bioimaging in live samples is of particular importance.

Recently, remarkable progresses have been achieved in in vitro biological detection and imaging based on organic fluorescent materials. However, organic fluorescent materials with strong two-photon (TP) absorption or near-infrared (NIR) emission for visualization of specific biological species, as well as monitoring in deep tissue and live animals, are still in high demand. In addition, specific visualization of important subcellular biological species, like proteins and related biological processes, remains a great challenge. Therefore, the integration of elegant organic synthesis, photophysical characterization, density functional theory, and molecular docking could help to prepare multiple functionalized organic fluorescent materials with strong TP absorption and NIR emission for in vitro, ex vivo, and in vivo fluorescent detection and imaging.

As such, this Research Topic aims to provide reasonable strategies to synthesize various organic fluorescent materials with versatile functionalities and multicolor emissions, as well as some new insights into their diverse biological applications—especially in biosensing and bioimaging.

In this Research Topic, original research articles, reviews, and perspectives are welcome from multiple disciplines. Research areas may include (but not limited to) the following:

 • Design and synthesis of novel small molecule-based fluorescent materials
 • Development of fluorescent bioprobes based on functionalized organic materials
 • Fluorescent detection of important biological species (ions, small molecules, maromolecules, etc.) and biological processes
 • Two-photon and near-infrared biomedical fluorescence imaging


Keywords: Organic fluorescent materials, Functionality, Biological application, Fluorescent detection, Fluorescence imaging


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

14 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

14 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..