Research Topic

Mechanisms and Novel Therapies in Graves’ Orbitopathy: Current Update

About this Research Topic

Graves' orbitopathy (GO) is characterized by inflammation of orbital connective tissues that develops in around 25-70% of patients with Graves' disease (GD). As the most common extrathyroidal manifestation of GD, the annual incidence of GO is three cases per 100,000 males and 16 cases per 100,000 females. GO has puzzled generations of clinicians and scientists because of its diverse clinical manifestations, obscure pathogenesis, and the challenges posed by its management. Typically, the natural history of GO includes an active, inflammatory stage, followed by chronic stabilization and quiescence status. It is recognized that the pathological processes of GO include inflammatory infiltration of various immune cells into retro-orbital tissues, de novo adipogenesis, and overproduction of extracellular matrix leading to fibrosis. Advances in recent years have helped elucidate some of the pathogenetic mechanisms of GO, particularly the genetic background, the immune response, the role of thyrotropin receptor and insulin-like growth factor 1 receptor. Although intravenous use of glucocorticoids has been established as a superior therapeutic approach, the use of immunomodulation therapy is currently being investigated. Results from some current clinical trails are promising.

The aim of this Research Topic is to highlight recent advances, new technologies, and challenges in the field of GO, especially the underlying mechanisms and targeted therapies. We have identified the following areas of GO research where new discoveries were made recently which have led to new questions and challenges for the future:

• Adipogenesis and fibrosis
• B cell and autoantibody
• Effector and regulatory T cell
• Emerging therapeutic agent
• Fibrocyte and orbital fibroblast
• Genetics and epigenetics of thyroid
• GO and GD animal model
• Microbiota and thyroid autoimmunity
• TSHR and IGF-1R crosstalk

With this Research Topi, we hope to further explore the pathogenesis and management of GO across specialties of endocrinology and ophthalmology. Original research, reviews, mini reviews, meta-analyses, perspectives, and general commentary and opinion will be considered as suitable material, and consideration of either human or animal data is encouraged.

*Credit for the cover image of this Research Topic goes to Chenyi Lin and Yi Lu


Keywords: Graves’ orbitopathy, Graves’ disease, Genetics, Autoimmunity, Immunotherapy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Graves' orbitopathy (GO) is characterized by inflammation of orbital connective tissues that develops in around 25-70% of patients with Graves' disease (GD). As the most common extrathyroidal manifestation of GD, the annual incidence of GO is three cases per 100,000 males and 16 cases per 100,000 females. GO has puzzled generations of clinicians and scientists because of its diverse clinical manifestations, obscure pathogenesis, and the challenges posed by its management. Typically, the natural history of GO includes an active, inflammatory stage, followed by chronic stabilization and quiescence status. It is recognized that the pathological processes of GO include inflammatory infiltration of various immune cells into retro-orbital tissues, de novo adipogenesis, and overproduction of extracellular matrix leading to fibrosis. Advances in recent years have helped elucidate some of the pathogenetic mechanisms of GO, particularly the genetic background, the immune response, the role of thyrotropin receptor and insulin-like growth factor 1 receptor. Although intravenous use of glucocorticoids has been established as a superior therapeutic approach, the use of immunomodulation therapy is currently being investigated. Results from some current clinical trails are promising.

The aim of this Research Topic is to highlight recent advances, new technologies, and challenges in the field of GO, especially the underlying mechanisms and targeted therapies. We have identified the following areas of GO research where new discoveries were made recently which have led to new questions and challenges for the future:

• Adipogenesis and fibrosis
• B cell and autoantibody
• Effector and regulatory T cell
• Emerging therapeutic agent
• Fibrocyte and orbital fibroblast
• Genetics and epigenetics of thyroid
• GO and GD animal model
• Microbiota and thyroid autoimmunity
• TSHR and IGF-1R crosstalk

With this Research Topi, we hope to further explore the pathogenesis and management of GO across specialties of endocrinology and ophthalmology. Original research, reviews, mini reviews, meta-analyses, perspectives, and general commentary and opinion will be considered as suitable material, and consideration of either human or animal data is encouraged.

*Credit for the cover image of this Research Topic goes to Chenyi Lin and Yi Lu


Keywords: Graves’ orbitopathy, Graves’ disease, Genetics, Autoimmunity, Immunotherapy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

22 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

22 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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