Research Topic

Programmed Cell Death 2.0: The Quality of Cell Death

About this Research Topic

As a fundamental biological process, actively programmed cell death has important implications for physiological processes. Studies over the past decades elucidated several key cell death signaling pathways as well as their possible consequences. From those studies, now we know the impacts of the cell death could go far beyond cellular demise. For example, cell death can modulate their micro-environment, such as inducing or inhibiting certain innate or adaptive immune system. It may also stimulate the neighbor cell proliferation, known as “compensatory proliferation”. Thus, we believe the next generation cell death studies are not only just to continue deciphering the cell death machinery. They will also expand to decode the physiological response to each specific mode of cell death mechanism. That is ”The Quality of Cell Death”.

In this Research Topic, we aim to showcase cutting-edge views on the consequences of programmed cell death and the mechanisms that determine those effects. We aim to cover promising, recent, and novel research trends exploring the relationship of cell death mechanisms and surrounding cell responses. Studies focused on epithelial malignancies and cell death are particularly welcome.

Original Research, Reviews, Mini-Reviews, and Hypothesis and Theory papers are welcome. Sub-topics may include, but are not limited to:

• Novel cell death mode discoveries.
• The roles of cell death in physiological and pathological processes, with particular attention to epithelial malignancies.
• Mechanisms that determine the physiological impacts of dead cells.
• The non-killing functions of the cell death machinery.
• Therapeutic implications of cell death regulation.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

As a fundamental biological process, actively programmed cell death has important implications for physiological processes. Studies over the past decades elucidated several key cell death signaling pathways as well as their possible consequences. From those studies, now we know the impacts of the cell death could go far beyond cellular demise. For example, cell death can modulate their micro-environment, such as inducing or inhibiting certain innate or adaptive immune system. It may also stimulate the neighbor cell proliferation, known as “compensatory proliferation”. Thus, we believe the next generation cell death studies are not only just to continue deciphering the cell death machinery. They will also expand to decode the physiological response to each specific mode of cell death mechanism. That is ”The Quality of Cell Death”.

In this Research Topic, we aim to showcase cutting-edge views on the consequences of programmed cell death and the mechanisms that determine those effects. We aim to cover promising, recent, and novel research trends exploring the relationship of cell death mechanisms and surrounding cell responses. Studies focused on epithelial malignancies and cell death are particularly welcome.

Original Research, Reviews, Mini-Reviews, and Hypothesis and Theory papers are welcome. Sub-topics may include, but are not limited to:

• Novel cell death mode discoveries.
• The roles of cell death in physiological and pathological processes, with particular attention to epithelial malignancies.
• Mechanisms that determine the physiological impacts of dead cells.
• The non-killing functions of the cell death machinery.
• Therapeutic implications of cell death regulation.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

16 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

16 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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