About this Research Topic
Powered by rapid technological developments, increasingly diverse types of biomarkers have been detected at genomic, transcriptomic, proteomic, metabolomic, immunomic, and cellular levels. While diverse sets of biomarkers have been utilized in cancer diagnosis, prognosis, treatment, and management, recent additions derived from lincRNA, circular RNA, circulating DNA together with its methylated and hydroxymethylated forms, and immune signatures are likely to further transform clinical practice.
With the aim of delineating the functionalities of molecular biomarkers and their interactions in driving cancer initiation and progression to aid in precision medicine, this Research Topic covers a wide spectrum of research interests that draw a holistic view to multiscale biomarkers with prospects of joint inference and in diverse use scenarios including predisposition, diagnosis, prognosis, and therapeutics. We welcome both computational and laboratory studies, as well as both preclinical and clinical efforts. Potential subtopics include, but are not limited to:
1. Novel biomarkers differentiating cancer heterogeneity that require many informed decisions from treatment to care with the help of genomic or epigenomic sequencing. Please note that studies proposing novel biomarkers must include molecular validation.
2. Identification of biomarkers, signature panels, pathways, or networks stratifying or rewiring cancer stemness for diagnostic and therapeutic purposes.
3. Augmentation of multiscale molecular biomarkers and assessment of their complementary advantages using computational or experimental approaches.
4. Characterization of the primary mechanisms of biomarkers that drive cancer heterogeneity and malignancy.
5. Novel computational or experimental techniques for identifying and capturing diverse types of cancer biomarkers based on their molecular features.
6. Clinical translation or efforts bridging the gap between our incremental knowledge on cancer biomarkers and the influence of these diversified biomarkers on clinical practice.
Topic Editor Dong-Qing Wei owns copyrights for software related to biomarker detection. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.