Research Topic

The Network of Inflammatory Mechanisms in Kidney Disease: Mechanism and New Therapeutic Agents

About this Research Topic

Many signalling pathways have been shown to be involved in the progression of kidney disease in humans and in animal models, usually due to persistent activation of these pathways. Perhaps the best well known of such pathways include certain inflammatory cytokines and protein kinase pathways, such as protein kinase C and mitogen-activated kinase pathways, which lead to cellular growth and fibrosis. Additionally, pathways such as angiotensin II and transforming growth factor-β signaling pathways, which enhance fibrosis leads to kidney scarring. Therefore, challenges in kidney disease include continuing to improve the advances in pathogenesis and molecular biology, and novel therapeutic options.

This Research Topic aims to update important aspects regarding kidney disease such as diabetic nephropathy, lupus nephritis, and vasculitis nephritis (i.e. anti-neutrophilic cytoplasmic antibodies associated vasculitis). We also aim to discuss new disease targets, description of potential pathologic pathways, and promising therapeutic approaches from basic science to clinical work.

Details for authors: Investigators working on animal models of renal injury such as autoimmune nephritis and clinical studies in these areas are encouraged to submit their work. For these purposes, we intend to include original, review and perspective articles, and commentaries. We hope this Research Topic will provide a broad update in several kidney diseases and will determine relevant advances in different aspects in the field. We do not encourage the submission of case reports unless they are in the context of a comprehensive review of relevant literature that may lead to changes in practice and treatment approaches.


Keywords: kidney disease, therapeutic agents, autoimmune disease, cytokines, protein kinase pathways


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Many signalling pathways have been shown to be involved in the progression of kidney disease in humans and in animal models, usually due to persistent activation of these pathways. Perhaps the best well known of such pathways include certain inflammatory cytokines and protein kinase pathways, such as protein kinase C and mitogen-activated kinase pathways, which lead to cellular growth and fibrosis. Additionally, pathways such as angiotensin II and transforming growth factor-β signaling pathways, which enhance fibrosis leads to kidney scarring. Therefore, challenges in kidney disease include continuing to improve the advances in pathogenesis and molecular biology, and novel therapeutic options.

This Research Topic aims to update important aspects regarding kidney disease such as diabetic nephropathy, lupus nephritis, and vasculitis nephritis (i.e. anti-neutrophilic cytoplasmic antibodies associated vasculitis). We also aim to discuss new disease targets, description of potential pathologic pathways, and promising therapeutic approaches from basic science to clinical work.

Details for authors: Investigators working on animal models of renal injury such as autoimmune nephritis and clinical studies in these areas are encouraged to submit their work. For these purposes, we intend to include original, review and perspective articles, and commentaries. We hope this Research Topic will provide a broad update in several kidney diseases and will determine relevant advances in different aspects in the field. We do not encourage the submission of case reports unless they are in the context of a comprehensive review of relevant literature that may lead to changes in practice and treatment approaches.


Keywords: kidney disease, therapeutic agents, autoimmune disease, cytokines, protein kinase pathways


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

23 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

23 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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