Research Topic

Acute Promyelocytic Leukemia - Towards a Chemotherapy-Free Approach to Cure in All Patients

About this Research Topic

Acute promyelocytic leukemia (APL) is characterized by a translocation denoted as t (15;17) (q24;21) and the fusion gene PML-RARA. With optimal supportive care and frontline use of all-trans retinoic acid (ATRA) and chemotherapy, first complete remission (CR1) rates of more than 90% and long-term survival of more 80% can be achieved. Intravenous arsenic trioxide (i.v.-As2O3 ) is highly efficacious for APL in first relapse (R1), inducing second complete remission (CR2) in more than 90% of patients. Oral preparations of As2O3 (oral-As2O3 ) have also been formulated, and it has been shown to induce CR2 in more than 90% of R1 patients. Oral-As2O3 has also been evaluated recently in frontline use and was shown to lead a favorable overall-survival (OS) and leukemia-free-survival (LFS), implying that prolonged oral-As2O3 treatment may prevent relapses.

Frontline treatment of APL has evolved rapidly. An emerging theme is the incorporation of As2O3 early in the treatment algorithm, starting from induction to consolidation. This Research Topic aims to provide an overview on the biology of APL, with past and present, and future perspectives on treatment approaches.


We welcome submissions in the form of Original Research and Review articles on the following topics (but not limited to):
- Biology of APL
- Evolution of therapeutic approaches for APL – past and present
- Reappraising the need for “risk-stratification” in the arsenic trioxide era
- Frontline arsenic trioxide-based induction for APL
- Reappraising the role of hematopoietic stem cells transplantation in the arsenic trioxide era
- Moving towards an entirely oral approach for APL – development of oral arsenic trioxide
- Resistance to all-trans-retinoic acid and arsenic trioxide – mechanisms and novel therapeutic approaches


Keywords: acute promyelocytic leukemia, biology, therapy, all-trans-retinoic acid, arsenic trioxide


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Acute promyelocytic leukemia (APL) is characterized by a translocation denoted as t (15;17) (q24;21) and the fusion gene PML-RARA. With optimal supportive care and frontline use of all-trans retinoic acid (ATRA) and chemotherapy, first complete remission (CR1) rates of more than 90% and long-term survival of more 80% can be achieved. Intravenous arsenic trioxide (i.v.-As2O3 ) is highly efficacious for APL in first relapse (R1), inducing second complete remission (CR2) in more than 90% of patients. Oral preparations of As2O3 (oral-As2O3 ) have also been formulated, and it has been shown to induce CR2 in more than 90% of R1 patients. Oral-As2O3 has also been evaluated recently in frontline use and was shown to lead a favorable overall-survival (OS) and leukemia-free-survival (LFS), implying that prolonged oral-As2O3 treatment may prevent relapses.

Frontline treatment of APL has evolved rapidly. An emerging theme is the incorporation of As2O3 early in the treatment algorithm, starting from induction to consolidation. This Research Topic aims to provide an overview on the biology of APL, with past and present, and future perspectives on treatment approaches.


We welcome submissions in the form of Original Research and Review articles on the following topics (but not limited to):
- Biology of APL
- Evolution of therapeutic approaches for APL – past and present
- Reappraising the need for “risk-stratification” in the arsenic trioxide era
- Frontline arsenic trioxide-based induction for APL
- Reappraising the role of hematopoietic stem cells transplantation in the arsenic trioxide era
- Moving towards an entirely oral approach for APL – development of oral arsenic trioxide
- Resistance to all-trans-retinoic acid and arsenic trioxide – mechanisms and novel therapeutic approaches


Keywords: acute promyelocytic leukemia, biology, therapy, all-trans-retinoic acid, arsenic trioxide


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

06 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

06 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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