Research Topic

Dynamical Networks of Life/Death Decisions in a Cell: From DNA Repair to Cell Death

About this Research Topic

The life/death decisions in the cell are controlled by the balance between apoptotic and anti-apoptotic signaling pathways such as DNA repair. Despite the fact these pathways have been studied relatively well, their quantitative regulation until recently has been poorly understood. This situation has dramatically changed in the last years. Creation of mathematical models of apoptotic and non-apoptotic signaling pathways led to an enormous progress in the quantitative understanding of the network regulation and provided fascinating insights into the mechanisms of life/death control. Moreover, it led to the identification of targets within the cell death networks followed by the drug discovery. In this Research topic, the computational models of apoptotic and non-apoptotic signaling and their biological implications will be addressed. Central attention will be given to the cross-talk between cell death and DNA repair pathways defining cell fate. Additionally, we also welcome methodology-related contributions aiming to list all possible methods available to address this topic.

We welcome Original Research, Methods and Review articles falling under the following aspects:

• Molecular and cellular mechanisms of DNA repair and apoptosis
• Recent advances associating cellular functions of DNA repair and apoptosis in health and disease
• Quantitative biology approaches in cell death and DNA repair research
• Cross-talk of DNA repair and apoptosis pathways
• Therapeutic strategies targeting the components of DNA repair and apoptosis
• Methods to evaluate the dynamics of the crosstalk between DNA repair and cell death


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The life/death decisions in the cell are controlled by the balance between apoptotic and anti-apoptotic signaling pathways such as DNA repair. Despite the fact these pathways have been studied relatively well, their quantitative regulation until recently has been poorly understood. This situation has dramatically changed in the last years. Creation of mathematical models of apoptotic and non-apoptotic signaling pathways led to an enormous progress in the quantitative understanding of the network regulation and provided fascinating insights into the mechanisms of life/death control. Moreover, it led to the identification of targets within the cell death networks followed by the drug discovery. In this Research topic, the computational models of apoptotic and non-apoptotic signaling and their biological implications will be addressed. Central attention will be given to the cross-talk between cell death and DNA repair pathways defining cell fate. Additionally, we also welcome methodology-related contributions aiming to list all possible methods available to address this topic.

We welcome Original Research, Methods and Review articles falling under the following aspects:

• Molecular and cellular mechanisms of DNA repair and apoptosis
• Recent advances associating cellular functions of DNA repair and apoptosis in health and disease
• Quantitative biology approaches in cell death and DNA repair research
• Cross-talk of DNA repair and apoptosis pathways
• Therapeutic strategies targeting the components of DNA repair and apoptosis
• Methods to evaluate the dynamics of the crosstalk between DNA repair and cell death


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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