About this Research Topic
RNA-binding proteins, and their interaction with messenger RNA (mRNA), play an important role in the regulation of translation and mRNA decay. The composition of RNA-protein complexes, such as messenger ribonucleoprotein (mRNP), determine whether an mRNA will undergo translation or be degraded. The association of specific RNA-binding proteins with mRNA could depend on one, or a combination, of following factors:
• The primary sequence of the mRNA
• The secondary structure of the mRNA
• Modifications of mRNA and/or proteins (such as RNA and protein methylation)
Several biological processes have highlighted the contribution of specific RNA-protein interactions in regulating mRNA translation and stability such as development, stem cell maintenance and differentiation, and aging and memory. The alteration of mRNP compositions is associated with many diseases such as cancer, AIDS, neurological disorders, and bacterial infectious diseases. Therefore understanding the principles of RNA-protein interactions in mRNA translation and decay is a critical step towards identifying the underlying mechanisms of proteome changes in healthy and disease conditions. Although numerous approaches are currently used to identify and analyze RNA-protein interactions, new technology enabling detection of weak and transient interactions will expand the catalog of these interactions.
The overall goal of this Research Topic is to highlight the new developments contributing to the understanding of RNA-protein interactions in mRNA translation and decay in normal and disease conditions.
‘RNA-Protein Interactions in mRNA translation and decay’ welcomes submissions of the following article types: Brief Research Report, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Technology and Code, Corrections and Perspective. Submissions are welcomed from, but not limited to, the following areas:
• New (or altered) RNA-protein interactions in mRNA translation and decay
• Role of post-translational modifications
• Role of mRNA modifications
• Phase transitions of RNA/protein/RNA-protein complexes
• RNA granules
• Modeling of RNA-protein interaction networks
• New technologies enabling detection of transient and/or weak RNA-protein interactions
Keywords: RNA-protein interactions, Translation, mRNA stability, RNA granules, Ribonucleases, Translation factors, messenger Ribonucleoproteins (mRNP), Translation repression
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