Research Topic

Metabolic Engineering of Microbial Electron Transport Chains and Energy-Coupling

About this Research Topic

The structure and function of microbial electron transport chains, together with membrane adenosine triphosphate (ATP) synthesis machinery, determine the catabolic ATP yield, intracellular redox balance, and, under oxic conditions, also the turnover of the reactive oxygen species (ROS). This common knowledge ...

The structure and function of microbial electron transport chains, together with membrane adenosine triphosphate (ATP) synthesis machinery, determine the catabolic ATP yield, intracellular redox balance, and, under oxic conditions, also the turnover of the reactive oxygen species (ROS). This common knowledge represents an obvious interest for biotechnological applications, as the engineering of energy-coupling systems should be able to manipulate key bioprocess parameters, like cell yield, productivity and stress resistance. Nevertheless, the bioenergetics of producer strains so far have received less attention from the metabolic engineering community, than it perhaps should. This might be because engineering of energy-coupling may sometimes elicit complex and unpredictable effects, particularly on the physiology of stress resistance, growth, and the performance of the central metabolism. With the advent of systems and synthetic biology tools however, it is time for the vast knowledge in microbial bioenergetics to find more focused metabolic engineering applications.

The present Research Topic welcomes work on engineering microbial energy metabolism, with the prime objective to improve the bioprocess performance of industrial strains: raising the yield and productivity of target product(s), controlling of cell yield, or increasing the robustness to various stress conditions. Studies of any metabolic type of traditional or potential (upcoming) producer microorganism are relevant for the Topic, including both chemotrophs and phototrophs. Manuscripts may have their emphasis either on experimental wet lab work or on modeling, or ideally, combine both approaches. As a result, we hope to obtain a comprehensive picture of recent developments in the field that could serve as a road-map to facilitate further research.

All types of articles are welcome, including Original Research, as well as Reviews and Perspective papers, devoted to:

• Manipulation of respiratory chain modules aimed at changing the net H+/O stoichiometry and/or kinetics of electron transport, in order to improve synthesis of the target product(s)
• Engineering of energy-coupling at the level of ATP synthase/ATPase and membrane transport reactions; design or elimination of futile cycles
• Respiratory redox cofactor engineering (e.g., modifying specificities towards NADH vs NADPH)
• Manipulation of the photosynthetic electron transport e.g., in microalgal or cyanobacterial producer strains
• Electron transport chain modifications enhancing the producer strain resistance to oxidative, thermal, pH, salt, lignocellulose hydrolysate inhibitor, osmotic, and other industrial stresses
• Fundamental studies investigating the impact of ATP/ADP or NADH/NAD+ perturbations on cellular performance using omics technology (e.g. transcriptomics, proteomics).
• The regulatory interactions of cellular energy management and metabolism


Keywords: Electron Transport, Energy-Coupling, Product Yield, Stress Resistance, Redox Balance


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 May 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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