Research Topic

Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence

About this Research Topic

Neuropsychiatric disorders such as schizophrenia, extrapyramidal disorders, Alzheimer's disease and other unrelated dementias, represent a serious human, medical and socioeconomic burden. These diseases are often accompanied by impairments of cognitive function, e.g., thinking, decision-making, and learning ...

Neuropsychiatric disorders such as schizophrenia, extrapyramidal disorders, Alzheimer's disease and other unrelated dementias, represent a serious human, medical and socioeconomic burden. These diseases are often accompanied by impairments of cognitive function, e.g., thinking, decision-making, and learning and memory. Such deficits significantly worsen quality of life and daily functioning of afflicted patients. Cognitive deficits in schizophrenia and other psychiatric diseases are associated with alterations of brain morphology and function, which are often resistant to therapeutic interventions.

In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, measurable phenotypes linking these complex disorders with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Experimental animal models may not mimic the full spectrum of clinical symptoms, but may work as analogies of particular behaviors or other disease manifestations. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, there is accumulated evidence showing (sometimes highly specific) deficits in cognition in these animal models of neuropsychiatric disorders. Moreover, there are a series of sensitive tests to measure cognitive performance in rodents and other species.

The primary focus of the present topic is to provide up-to-date information on cognitive deficits of central nervous system (CNS) disorders, and delineate future directions for translational studies aimed at developing novel treatments/interventions of these disturbances, both at clinical and preclinical levels.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top