About this Research Topic
Oxidative stress is defined as an imbalance between free radicals and antioxidants in the body. Reactive oxygen species (ROS) are oxygen-containing molecules that allow them to react with other molecules quickly. ROS and free radicals can cause large chain chemical reactions in the body and potentially induce tissue damage. This is particularly evident in patients with obesity and metabolic disorders. The topic here is on the importance of oxidative stress and how antioxidants prevent tissue damage regulating signal transduction pathways and gene expression at the cellular and tissue levels to improve outcomes.
We invite investigators to contribute original research articles as well as review articles that will highlight the emerging role of antioxidants in reducing oxidative stress, and how specific signaling pathways and transcriptional programs are impacted. We are particularly interested in original research articles describing the role of antioxidants in the prevention of obesity and related disorders, including hypertension, heart disease, atherosclerosis, kidney disease, diabetes, and stroke.
In this Research Topic, we welcome manuscripts addressing the below specific themes, but not limited to:
• Antioxidants in the prevention of obesity and related disorders, including hypertension, heart disease, atherosclerosis, kidney disease, diabetes, and stroke.
• Nuclear receptors and signal transduction pathways
• Oxidative stress, transcription factors, gene regulation and signal transduction pathways
• Obesity and obesity-related disorders and ROS
• Diabetes and ROS
• Cardiovascular disease, antioxidants, and oxidative stress
Topic Editors Terry Hinds and David Stec have submitted patents related to bilirubin and obesity related disorders. The other Topic Editor declare no potential conflicts of interest with regards to the Research Topic subject.
Keywords: ROS, antioxidants, transcription factors, signaling pathways, obesity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.