About this Research Topic
Behçet's disease (BD) is a chronic, relapsing inflammatory, multisystem disease of unknown aetiology. Its clinical features include mucocutaneous lesions and ocular, vascular, articular, neurologic, gastrointestinal, urogenital, pulmonary, and cardiac involvement. In this Research Topic, we will try to highlight the dermatological aspect of the disease. However, due to its multisystemic nature, we will also try to deal with BD from all other aspects. Therefore, we think that this Research Topic will attract attention from many disciplines.
The goal of this Research Topic is to bring the most recent developments in BD to a close, and further to review the current state of knowledge regarding the epidemiology, etiopathogenesis, clinical features, diagnosis, differential diagnosis and treatment of BD.
In this Research Topic, we would like to address the following themes:
• Diagnosis in most patients can only be made clinically on the basis of mucocutaneous symptoms which figure prominently in presentation and diagnosis. These are the hallmarks of BD. We would like to emphasize the importance of mucocutaneous findings and summarize the dermatological approach to this issue
• The Skin Pathergy Test (SPT), a non-specific tissue hyperreactivity reaction due to trauma, is one of the diagnostic criteria for BD. Controversy exists as to the sensitivity of this phenomenon which varies between geographic areas. We would like this Research Topic to address the importance of SPT in BD
• BD is still associated with severe morbidity because of mucocutaneous, articular and ocular symptoms and increased mortality due to the involvement of large vessel, neurologic, gastrointestinal, and cardiac factors. We want to review all these heterogeneous clinical features in all age groups.
• We will also address the epidemiological similarities and differences in BD among the countries with the most recent developments in epidemiology.
• Advances in understanding the etiopathogenesis and genetics of BD help us to facilitate the development of agents targeting specific inflammatory responses in the disease. Several recent GWASs have confirmed the association of BD with HLA-B*51 and reported new susceptibility genes both on the remaining part of HLA Class I region and on non-HLA genes. As such, we invite novel research on recent developments approaching these disease mechanisms and the role of microbiota in BD
• There are some controversial topics in BD, such as the role of anticoagulants in the treatment. We would like authors to discuss the best solutions for these controversial issues furthermore what can be done in the future of BD.
• Finally, based on the mainly controlled studies and personal experience in clinical practice and basic research in this field, we also welcome stepwise, symptom-based, algorithmic approaches for the management.
In this Research Topic, we hope to explain all aspects of BD to readers with a holistic approach, addressing all aspects of the disease as mentioned above.
Keywords: Behçet's disease, Etiopathogenesis, Mucocutaneous, Inflammatory Disorder, Dermatology
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