Research Topic

The Genetic and Epigenetic Bases of Cellular Response to Ionizing Radiation

About this Research Topic

Ionizing radiation (IR) is a severe DNA-damaging agent, which can induce extensive genomic instability and lead to serious consequences for cells and organisms, including cancer. IR can also determine hereditary effects and radiation-induced diseases thus representing a major concern for human population health. IR affects a very large number of processes in the cellular environment and can cause changes in gene expression, hamper functions of cellular organelles, induce cell cycle arrest, and lead to apoptotic cell death. The outcomes of these responses primarily depend upon the level and type of radiation as well as the genetic background of the irradiated cell or organism and epigenetic factors. This is particularly important when also the potential long-term effects of IR-induced genomic instability (i.e., transgenerational effects) are considered.

In this Research Topic we welcome Original Research papers and Reviews describing how the genetic landscape of a cell and/or organism can influence the response to IR, the contribution of the dose or dose rate on determining IR-induced genomic instability, and the roles played by epigenetic modifications (i.e., DNA methylation, histone modifications and ncRNAs) in the inheritance of transgenerational effects.


Keywords: ionizing radiation, transgenerational effects, epigenetic modification, chromosome integrity, genome stability, radioadaptive response


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Ionizing radiation (IR) is a severe DNA-damaging agent, which can induce extensive genomic instability and lead to serious consequences for cells and organisms, including cancer. IR can also determine hereditary effects and radiation-induced diseases thus representing a major concern for human population health. IR affects a very large number of processes in the cellular environment and can cause changes in gene expression, hamper functions of cellular organelles, induce cell cycle arrest, and lead to apoptotic cell death. The outcomes of these responses primarily depend upon the level and type of radiation as well as the genetic background of the irradiated cell or organism and epigenetic factors. This is particularly important when also the potential long-term effects of IR-induced genomic instability (i.e., transgenerational effects) are considered.

In this Research Topic we welcome Original Research papers and Reviews describing how the genetic landscape of a cell and/or organism can influence the response to IR, the contribution of the dose or dose rate on determining IR-induced genomic instability, and the roles played by epigenetic modifications (i.e., DNA methylation, histone modifications and ncRNAs) in the inheritance of transgenerational effects.


Keywords: ionizing radiation, transgenerational effects, epigenetic modification, chromosome integrity, genome stability, radioadaptive response


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

12 June 2020 Abstract
09 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

12 June 2020 Abstract
09 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..