Research Topic

Organ Fibrosis: Pathogenesis, Biomarkers and Therapeutic Targets

About this Research Topic

The prevalence of various chronic diseases is on the rise. Examples of such diseases include chronic kidney disease and non-alcoholic fatty liver disease, all of which are associated with high levels of morbidity and mortality, and significantly impact health-care budgets. A hallmark of these conditions is the development of fibrosis in the affected organ. Fibrosis is characterized by the excessive production and deposition of extracellular matrix proteins, mainly by activated myofibroblasts. This has a detrimental impact on organ architecture and function, ultimately necessitating organ transplantation. The fibrotic process is orchestrated by a wide variety of different cells and signalling pathways, which tremendously complicates the identification of relevant biomarkers and druggable therapeutic targets. Consequently, there is still no approved treatment available in clinical practice for most forms of organ fibrosis. Thus, there remains an unmet clinical need.

In this Research Topic, we wish to provide:

• A timely overview of the disease- and organ-specific pathogenesis of fibrosis;
• A summary of novel means to (non-invasively) monitor the development and progression of fibrosis in various diseases, thereby aiding in the identification of clinically-relevant diagnostic and prognostic biomarkers;
• Lastly, a summary of recent advances in the field of anti-fibrotic drug development.

The submission of original experimental work on organ fibrosis to this Research Topic is greatly welcomed.


Keywords: Cirrhosis, Renal Fibrosis, Pulmonary Fibrosis, Chronic Kidney Disease, Non-alcoholic Fatty Liver Disease


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The prevalence of various chronic diseases is on the rise. Examples of such diseases include chronic kidney disease and non-alcoholic fatty liver disease, all of which are associated with high levels of morbidity and mortality, and significantly impact health-care budgets. A hallmark of these conditions is the development of fibrosis in the affected organ. Fibrosis is characterized by the excessive production and deposition of extracellular matrix proteins, mainly by activated myofibroblasts. This has a detrimental impact on organ architecture and function, ultimately necessitating organ transplantation. The fibrotic process is orchestrated by a wide variety of different cells and signalling pathways, which tremendously complicates the identification of relevant biomarkers and druggable therapeutic targets. Consequently, there is still no approved treatment available in clinical practice for most forms of organ fibrosis. Thus, there remains an unmet clinical need.

In this Research Topic, we wish to provide:

• A timely overview of the disease- and organ-specific pathogenesis of fibrosis;
• A summary of novel means to (non-invasively) monitor the development and progression of fibrosis in various diseases, thereby aiding in the identification of clinically-relevant diagnostic and prognostic biomarkers;
• Lastly, a summary of recent advances in the field of anti-fibrotic drug development.

The submission of original experimental work on organ fibrosis to this Research Topic is greatly welcomed.


Keywords: Cirrhosis, Renal Fibrosis, Pulmonary Fibrosis, Chronic Kidney Disease, Non-alcoholic Fatty Liver Disease


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

14 June 2020 Abstract
12 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

14 June 2020 Abstract
12 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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