About this Research Topic
Over the last decade, a subpopulation of stem-like cancer cells has been identified as cancer stem cells (CSCs) that are characterized by self-renewal capacity and great potential of giving rise to new tumors. CSCs are believed to be responsible for tumorigenesis, relapse, metastases, as well as chemo-resistance in cancers. However, the origin, properties and regulatory network of CSCs remain unclear. Current advances in understanding the non-coding genome adds an additional dimension to the regulatory network of CSCs in control of cancer development and progression.
This Research Topic aims at highlighting current advances with in-depth studies and investigations on the origin, properties and heterogeneity of CSCs, and regulatory network by non-coding and coding genomes. In addition, it will expand to cover the study of translational research on developing novel therapeutic strategies targeting CSCs in prevention of cancer metastasis, relapse and drug-resistance.
We welcome Original Research articles. Reviews should be discussed with the topical editors before submission. Areas to be covered in this Research Topic may include, but are not limited to:
-Studies to determine the gene mutation accumulation in tissue stem cells causing the formation of CSCs
-Studies on cells-of-origin in cancer related with CSCs.
-Studies on identification of novel biomarkers to distinguish CSCs from cancer cells.
-Studies on therapeutic strategies targeting CSC heterogeneity.
-Studies on the correlations between circulating tumor cells, chemo-resistant tumor cells and CSCs.
-Studies on the novel mechanism of non-coding genome including miRNA, piRNA, lncRNA and circRNA in regulating CSCs.
Keywords: Cancer stem cells, cells-of-origin of cancer, tumor heterogeneity, non-coding genome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.