Research Topic

Modulators of Skeletal Muscle Hypertrophy: Mechanisms to Lifestyle Strategies

About this Research Topic

Skeletal muscle is a remarkable tissue that can remodel itself to suit the physical (e.g., mechanical load), environmental (e.g., heat or cold stress), and nutritional (e.g., amino acid availability) milieu to which it is exposed. However, the regulation of muscle mass is complex, with many fundamental ...

Skeletal muscle is a remarkable tissue that can remodel itself to suit the physical (e.g., mechanical load), environmental (e.g., heat or cold stress), and nutritional (e.g., amino acid availability) milieu to which it is exposed. However, the regulation of muscle mass is complex, with many fundamental knowledge gaps existing pertaining to mechanisms governing the processes of protein synthesis and protein breakdown. Ongoing insights into the physiological modulators of muscle mass regulation, are required to formulate optimal approaches to promote and maintain muscle mass and function across the life span.

In addition to understanding the molecular mechanisms governing muscle mass regulation, research is required to more comprehensively evaluate possible contributory lifestyle and therapeutic approaches. Studies addressing exercise or rehabilitation modalities, varying in frequency, volume and load regimes are required. These studies can be informed by novel and experimental stimuli such as training with blood flow restriction, peri- or post-exercise exposure to thermal stimuli, or other.

The proposed Research Topic ‘Modulators of skeletal muscle hypertrophy: Mechanisms to Lifestyle Strategies’ will consider relevant research articles from multiple perspectives; from investigations of the basic molecular and cellular biology of muscular adaptation, to applied sciences, and the combination of the two. We will happily consider submissions spanning the fields of exercise, nutritional supplementation, and muscle function; spanning the spectrum from the fundamental mechanisms which regulate myofiber size, to strategies to promotion muscle adaptations. Submissions encompassing a combination of the above approaches, or incorporating contributory elements of molecular biology, metabolism, or genetic regulation will be most welcomed. Original research investigations and review articles will both be considered, as we aim for this Research Topic to be an interesting and thought-provoking collection of articles that can assist in further developing this worthwhile and fascinating field.

Original research that contributes to the below themes will be considered:

• Studies that investigate novel interventions, including; training regimens, lifestyle and nutrition to enhance hypertrophy and/or muscular strength.
• Studies that analyze the molecular mechanisms that regulate hypertrophy and/or muscular strength.
• Studies that investigate the above themes in conditions or population groups at risk of muscle loss and weakness.


Keywords: Muscle hypertrophy, Exercise, Cellular and molecular, Protein synthesis, Translation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

03 August 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

03 August 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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