Research Topic

Pluripotent Cells for Stroke: from Mechanism to Therapeutic Strategies

About this Research Topic

Stroke is an acute central nervous system injury caused by cerebral ischemia or cerebral hemorrhage. It is the 5th cause of death and the leading cause of long-term disability in the US. With the progress in early diagnosis, mini-invasive surgery, and advanced intensive care support, stroke survival rate has increased dramatically. Nevertheless, these survivors usually suffer from sequelae of neurological impairments and psychiatric disorders, which affect their daily functionality and working capacity. Although extensively studied, the molecular mechanisms underlying stroke pathophysiology remain not fully understood and innovative therapies for stroke are urgently needed.

In recent years, pluripotent cell-based approaches have attracted more attention from scientists and physicians due to their possible neuroprotective and neural restorative effects on stroke. In addition, basic research on naïve and differentiated pluripotent cells including iPS cells has markedly improved our understanding of cellular and molecular mechanisms of stroke and provides a platform for the discovery of novel drug targets.

The aims of this Research Topic are to update the current understanding and future directions of pluripotent cell for stroke in mechanisms, bioengineering, translational and clinical researches. We will gladly consider original researches, reviews, perspectives, and commentaries covering the topic about pluripotent cell for stroke (including neural stem cells, iPS cells, mesenchymal stem cells, pericytes, various precursor cells, etc.) to achieve neural regeneration and repair neural function.

Potential topics include but are not limited to the following:
• Role and mechanism of resident pluripotent cells, such as neural stem cells, various precursor cells, pericytes, etc., in the pathophysiological process of secondary brain injury after stroke.
• Microenvironment for the pluripotent cells' variability, proliferation, differentiation and function restoration after stroke.
• Pluripotent cell-based therapeutic strategies and mechanism for the neurological recovery, as well as the clinical trials.
• Induced pluripotent stem cells and their potential application in stroke treatment.
• The pluripotent character of pericytes for the neural regeneration after Stroke
• In vivo tracking techniques of pluripotent cells in host brain, particularly using molecular imaging technique.
• Novel biotechnology of the pluripotent cell-based therapeutic strategies for stroke treatment.


Keywords: Stroke, Stem Cell, Pericyte, Microenvironment, Biotechnology, Neurogenesis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Stroke is an acute central nervous system injury caused by cerebral ischemia or cerebral hemorrhage. It is the 5th cause of death and the leading cause of long-term disability in the US. With the progress in early diagnosis, mini-invasive surgery, and advanced intensive care support, stroke survival rate has increased dramatically. Nevertheless, these survivors usually suffer from sequelae of neurological impairments and psychiatric disorders, which affect their daily functionality and working capacity. Although extensively studied, the molecular mechanisms underlying stroke pathophysiology remain not fully understood and innovative therapies for stroke are urgently needed.

In recent years, pluripotent cell-based approaches have attracted more attention from scientists and physicians due to their possible neuroprotective and neural restorative effects on stroke. In addition, basic research on naïve and differentiated pluripotent cells including iPS cells has markedly improved our understanding of cellular and molecular mechanisms of stroke and provides a platform for the discovery of novel drug targets.

The aims of this Research Topic are to update the current understanding and future directions of pluripotent cell for stroke in mechanisms, bioengineering, translational and clinical researches. We will gladly consider original researches, reviews, perspectives, and commentaries covering the topic about pluripotent cell for stroke (including neural stem cells, iPS cells, mesenchymal stem cells, pericytes, various precursor cells, etc.) to achieve neural regeneration and repair neural function.

Potential topics include but are not limited to the following:
• Role and mechanism of resident pluripotent cells, such as neural stem cells, various precursor cells, pericytes, etc., in the pathophysiological process of secondary brain injury after stroke.
• Microenvironment for the pluripotent cells' variability, proliferation, differentiation and function restoration after stroke.
• Pluripotent cell-based therapeutic strategies and mechanism for the neurological recovery, as well as the clinical trials.
• Induced pluripotent stem cells and their potential application in stroke treatment.
• The pluripotent character of pericytes for the neural regeneration after Stroke
• In vivo tracking techniques of pluripotent cells in host brain, particularly using molecular imaging technique.
• Novel biotechnology of the pluripotent cell-based therapeutic strategies for stroke treatment.


Keywords: Stroke, Stem Cell, Pericyte, Microenvironment, Biotechnology, Neurogenesis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

17 July 2020 Abstract
14 November 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

17 July 2020 Abstract
14 November 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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