Research Topic

Gastric Cancer Phenotype and Treatment

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A growing body of evidence has shown several differences in the natural behaviour of gastric cancer. These phenotypical differences reveal the existence of various gastric cancer subtypes. A modern approach to gastric cancer management would be to follow a personalized treatment based on these subtypes, ...

A growing body of evidence has shown several differences in the natural behaviour of gastric cancer. These phenotypical differences reveal the existence of various gastric cancer subtypes. A modern approach to gastric cancer management would be to follow a personalized treatment based on these subtypes, classified either with traditional pathology, immunohistochemistry, molecular analysis, or other strategies. These subtypes may gain a different benefit from specific surgical strategies, may be associated to a different response to chemotherapy, radiotherapy, and molecular therapy, and to a different prognosis.

Giving attention to studies focusing on the description of the specific features of these gastric cancer subtypes represents a promising line of research, with the potential to obtain results with significant clinical impact, that may cause a paradigm shift in the standard of care for this disease.

The scope of this Research Topic is to promote investigations aimed to identify the specific characteristics and the predictive and prognostic value of the various types of gastric cancer. We welcome Review or Original Research manuscripts in the preclinical, translational and clinical field that explore, but are not limited to, the following list of themes:

● Image analysis and molecular genetics in gastric cancer pathology
● "Omics" sciences and their possible impact on gastric cancer treatment
● Molecular classification of gastric cancer
● Biomarkers in gastric cancer, with special attention to those related to a specific subtype
● Characterization of the different microenvironment associated with the different subtypes of gastric cancer
● Evidences on the different natural behaviour of the different subtypes of gastric cancer
● Surgical strategies for the treatment of gastric cancer targeted on the different stage and/or subtype (i.e. extended lymphadenectomy, prophylactic HIPEC)
● Outcomes of surgery in the treatment of different subtypes of gastric cancer
● New targeted strategies for the adjuvant and/or neoadjuvant treatment of the different subtypes of gastric cancer


Keywords: gastric cancer, phenotype, treatment, gastric cancer subtype, gastric cancer phenotype


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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