Research Topic

Emerging Mechanisms for Skeletal Muscle Mass Regulation

About this Research Topic

Skeletal muscle, an essential organ in locomotion, respiration, and metabolism, is composed of the many muscle cells known as myofiber. As with each myofiber being under the post-mitotic state, the muscle cannot grow via cellular division. Instead, it can volumetrically expand by increasing the cellular ...

Skeletal muscle, an essential organ in locomotion, respiration, and metabolism, is composed of the many muscle cells known as myofiber. As with each myofiber being under the post-mitotic state, the muscle cannot grow via cellular division. Instead, it can volumetrically expand by increasing the cellular volume per myofiber. Inversely, the volume can decrease under certain conditions. The quantitative adaptability of myofiber change also attributes to biological conditions such as age, sex, and race. In principle, the larger volume of muscle is favorable for our lives; the muscle cross-sectional area is proportional to the muscle force production. Nevertheless, we still have no means to control skeletal muscle mass at will.

Recent progress in the field of muscle research have revealed underlying mechanisms on volumetric regulation of skeletal muscle from various aspects including; both the universal system as that of multiple cell types and the myocyte specific system. In recent years, the skeletal muscle mass revealed to be complicatedly involved with inherent and environmental factors, and many signaling pathways associated with these factors. However, the entire picture of muscle mass regulation remains unclear. The effects of multi-organ networks on skeletal muscle mass regulation are also poorly understood. In this topic, we aim to obtain new knowledge for the basis of muscle volumetric regulation. The proposed knowledge will contribute to improve the quality of life of the general and sick populations, athletes, as well as people engaged in special tasks such as spaceflight.

We seek original articles within the research areas listed below. Other topics are also welcome if the content fits the scope of the Research Topic. Every manuscript, however, is encouraged to propose new molecular/signaling-based mechanisms to elucidate muscle mass regulation.

 Novel signaling mechanisms of skeletal muscle hypertrophy and atrophy
 Development of novel strategy to facilitate muscle hypertrophy
 Development of novel strategy to prevent/attenuate muscle atrophy
 Multi-organ relationships in muscle mass regulation
 The novel role of myokines to regulate muscle hypertrophy and atrophy
 Novel mechanisms of sex-difference in muscle mass regulation
 Emerging food and natural/artificial compounds to regulate muscle mass
 Molecular mechanisms for muscle mass regulation in extreme environment
 Effect of exercise training and detraining on signaling mechanisms of muscle mass control


Keywords: Myocyte, Hypertrophy, Atrophy, Adaptation, Environment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

21 February 2021 Manuscript
21 March 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

21 February 2021 Manuscript
21 March 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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