Research Topic

Genomic Architecture of Cardiovascular Diseases

About this Research Topic

Cardiovascular disease is caused by a combination of genetic factors and environmental factors. Several variants in the genome affect functions of genes, which changes molecular interactions or signal transduction, leading to alterations in cellular or organ functions. Environmental factors influence cellular ...

Cardiovascular disease is caused by a combination of genetic factors and environmental factors. Several variants in the genome affect functions of genes, which changes molecular interactions or signal transduction, leading to alterations in cellular or organ functions. Environmental factors influence cellular signaling pathways, transcriptional mechanisms, and epigenomic profiles, generating changes in cell identity.

Rare cardiovascular diseases, such as cardiomyopathy and pulmonary hypertension, were mainly caused by single nucleotide variants and were considered to be monogenic pathogenesis. Integrative analysis of genotypes and clinical phenotypes have revealed the specific genotype-phenotype associations. For example, LMNA-related cardiomyopathy shows poor response to treatment and poor prognosis. Recently, some cardiomyopathies have been explained by a combination of the genetic factors (TTN truncating mutations) and the environmental factors (pregnancy, anti-cancer agents, alcohol drinking).
Common cardiovascular diseases, such as coronary artery disease and atrial fibrillation, were mainly caused by environmental factors, such as hypertension, diabetes, hyperlipidemia, and smoking. However, twin studies have revealed high heritability of these common cardiovascular diseases. Actually, genome-wide association studies (GWAS) have identified the disease-associated single-nucleotide polymorphisms (SNPs), leading to the development of polygenic risk scores to assess genetic burdens for each patient.
Therefore, we have to consider a combination of genetic and environmental factors to deeply understand the pathogenesis of cardiovascular diseases. These knowledge structures will enable us to establish the fundamental basis of precision cardiovascular medicine.

The aims of the current Research Topic are: (1) to review the current knowledge about genomic architecture of rare and common cardiovascular diseases and their clinical applications; (2) to introduce innovative researches for identifying novel genomic factors for cardiovascular diseases; (3) to show cutting-edge researches elucidating disease architectures by integrating genomic information with other omics datasets (including single-cell datasets); (4) to provide a future perspective for the development of precision cardiovascular medicine, for example by combining with molecular pathology. We welcome Original Research, Review, and Perspective papers in genomic architecture in cardiovascular disease.


Keywords: Cardiovascular disease, Genome, Omics analysis, Data integration, Precision medicine


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

08 December 2020 Manuscript
08 January 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

08 December 2020 Manuscript
08 January 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..