About this Research Topic
The genome is threatened by both endogenous (i.e., DNA replication and recombination errors) and exogenous (i.e., UV, ionizing radiation) threats, resulting in DNA damage. Accurate and effective repair promotes cell survival, inefficient repair that leads to survival of gnomically unstable cancer cells, and induction of apoptosis if the damage is severe and irreparable. As a hallmark of cancer, genomic instability has always been associated with cancer development and drug resistance. At the same time, genomic instability can also provide effective and correct targets and strategies for cancer treatment. Therefore, specifically targeting DNA damage or repair pathways in cancer cells to induce cell death is the target of biological precision cancer therapy.
The relationship between endonuclear repair proteins and DNA damage repair pathways during carcinogenesis and treatment has been widely studied. However, the interaction between extra-nuclear subcellular organelles (e.g., mitochondria, endoplasmic reticulum, lysosomes, etc.) and DNA damage response has been rarely studied. This Research Topic focuses on elucidating the role of different extra-nuclear subcellular organelles in the process of DNA damage or repair. In this Research Topic, we aim to provide a comprehensive introduction to cancer therapies mainly targeting DNA damage response and provide new insights into cancer treatment with extra-nuclear subcellular organelles.
We welcome Original Research and Review articles covering the latest and current research on the role of extra-nuclear subcellular organelles in DNA damage and repair in cancer therapies. Articles can describe different aspects of genetic, cellular, biochemical, structural, and molecular understandings of the role of extra-nuclear subcellular organelles with DNA damage or repair pathways, inducing chemo and radioresistance, and its importance as key prognostic, predictive, and therapeutic targets in cancer.
This Research Topic will cover, but is not limited to, the following subtopics:
• Extra-nuclear subcellular organelles (such as mitochondria, endoplasmic reticulum, lysosomes, etc) participation in the material and information exchange process of the nucleus;
• Analyzing the key signaling targets of subcellular organelle interaction network in regulating DNA damage response;
• Extra-nuclear subcellular organelle key proteins may serve as prognostic, predictive and therapeutic targets for cancer;
• Mechanisms of key proteins of extra-nuclear subcellular organelles involved in chemo and radioresistance in cancers;
• Research on combination therapy in cancer treatment by targeting DNA damage or repair pathways.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.