E3 Ub-ligases group into four main types: the RING (really-interesting new gene) family, the U-box family, the HECT (homologous to the E6AP carboxyl terminus) family, and the RBR (RING-in-between-RING) family. The RING family is by far the largest class, and is divide into multiple subfamilies, including the monomeric/dimeric/heterodimeric RINGs, the anaphase-promoting complex/cyclosome (APC/C), and the Cullin-RING ligases. Higher eukaryotes encode large numbers of E3s in their genomes, and this is particularly so in plants. Arabidopsis thaliana, for instance, has >1,400 loci encoding potential E3s or E3 subunits. While there has been significant effort to elucidate the targets and functions of individual E3s in plants, to date the targets of the majority have yet to be determined. In addition, there is still much that we don’t understand about the nature and regulation of E3-ligase/target interactions and about the co-evolution of E3s and their targets.
This Research Topic welcomes Original Research, Reviews, Mini Reviews, and Opinion articles providing new insights into structure, function, and evolution of E3 ligases and targets. Topics can include: •\tIdentification of new E3 targets in plants •\tCharacterization of the structure of E3/target complexes •\tIdentification of mechanisms that regulate E3/target interactions •\tStudies exploring the evolution of E3 Ub-ligases and their targets","datePublished":"30 Jun 2020","editor":[{"@id":"https://loop.frontiersin.org/people/683012/overview","@type":"Person","name":"Derek Gingerich","affiliation":[{"@type":"Organization","name":"University of Wisconsin–Eau Claire","location":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":null,"addressCountry":null}}}],"jobTitle":"Topic Editor"},{"@id":"https://loop.frontiersin.org/people/952468/overview","@type":"Person","name":"Matthew James Christians","affiliation":[{"@type":"Organization","name":"Grand Valley State University","location":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":null,"addressCountry":null}}}],"jobTitle":"Topic Editor"},{"@id":"https://loop.frontiersin.org/people/107745/overview","@type":"Person","name":"Sophia Stone","affiliation":[{"@type":"Organization","name":"Dalhousie University","location":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":null,"addressCountry":null}}}],"jobTitle":"Topic Editor"},{"@id":"https://loop.frontiersin.org/people/25775/overview","@type":"Person","name":"Hanjo A Hellmann","affiliation":[{"@type":"Organization","name":"Washington State University","location":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":null,"addressCountry":null}}}],"jobTitle":"Topic Editor"},{"@id":"https://loop.frontiersin.org/people/25937/overview","@type":"Person","name":"Qi Xie","affiliation":[{"@type":"Organization","name":"Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (CAS)","location":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":null,"addressCountry":null}}}],"jobTitle":"Topic Editor"}],"inLanguage":"en","license":"CC BY 4.0","URL":"https://www.frontiersin.org/research-topics/14852/structure-function-and-evolution-of-e3-ligases-and-targets/magazine"}
Structure, Function, and Evolution of E3 Ligases and Targets
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Structure, Function, and Evolution of E3 Ligases and Targets
CONSTITUTIVE PHOTOMORPHOGENIC 1 functions as an E3 ubiquitin ligase in plants and animals. Discovered originally in Arabidopsis thaliana, COP1 acts in a complex with SPA proteins as a central repressor of light-mediated responses in plants. By ubiquitinating and promoting the degradation of several substrates, COP1/SPA regulates many aspects of plant growth, development and metabolism. In contrast to plants, human COP1 acts as a crucial regulator of tumorigenesis. In this review, we discuss the recent important findings in COP1/SPA research including a brief comparison between COP1 activity in plants and humans.