Research Topic

Lactate as a Major Signaling Molecule for Homeostasis

About this Research Topic

For a long time, L-lactate has been considered as a waste product of glycolysis due to oxygen deficiency. Lactate changes and metabolism were only investigated in sport science in order to delay muscle alteration and acidosis for improving performance. Today, the interest in lactate has gone far beyond the ...

For a long time, L-lactate has been considered as a waste product of glycolysis due to oxygen deficiency. Lactate changes and metabolism were only investigated in sport science in order to delay muscle alteration and acidosis for improving performance. Today, the interest in lactate has gone far beyond the circle of physical exercise to extend to a growing number of disciplines, from physiology to pathology. In fact, lactate can enter into the cell-to-cell lactate shuttle and be a major coordinator of whole-body metabolism. Lactate is now recognized as a major signaling molecule at cellular, organ, and tissue levels. Thus, understanding how lactate can modulate such different physiological and pathological processes is a crucial importance for health issues.

There are many situations associated with alterations in L- lactate concentrations independently of exercise condition. The resulting signaling pathway modulations could contribute to beneficial/deleterious outcomes of lactate variations. In fact, several properties of lactate have been identified, and as an example, lactate could be beneficial due to its anti-inflammatory activities and represent a promising therapy for limiting inflammatory disorders. However, a recent study has shown that lactate could act as an onco-metabolite and as such could participate in cancer development. These different properties of lactate, depending on cell types, tissues, or circumstances lead to difficult handling of lactate variations in clinical use. Moreover, recent data highlight a major role for the lactate molecule in physiological processes such as the immune response, muscle growth, neuron metabolism, tissues metabolic switch, epigenetic processes, angiogenesis but also in pathological processes such as sepsis, tumorigenesis, ischemia, etc. Thus, lactate plays a central role in many fundamental processes.

This Research Topic aims to highlight the many roles of lactate in order to better understand the signaling pathways implicated, but also to develop new strategies for lactate handling and clinical decision. This Research Topic welcomes in vitro, ex vivo and in vivo studies investigating signaling pathways in relation with lactate alteration.

The Guest-Editors of this Research Topic welcome original research articles, reviews, brief research reports and perspectives highlighting, but not limited to the following topics focusing on lactate:

• Redox alteration in physiology and pathology
• Signaling pathways regulated by lactate
• Lactate in physiology and pathology
• Clinical studies with lactate handling
• Sport sciences and lactate

Topic Editor Dr. Philippe Connes has received a grant from HARTIS Pharma (Switzerland-France). All other Topic Editors declare no competing interests with regards to the Research Topic subject.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

26 February 2021 Manuscript
31 March 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

26 February 2021 Manuscript
31 March 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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