About this Research Topic
Immune-mediated diseases is a group of conditions that result from abnormal activity of the immune cells, overreacting or attacking to the body, displaying an extreme inflammatory response or loss of the ability to recognize and fight against tumor cells. Systemic lupus erythematous, rheumatoid arthritis, Takayasu syndrome, diabetes type 1, allergy, and cancer are considered to be immune-mediated diseases. The causes of these entities have been attributed to environmental and living conditions, along with host factors. Environmental factors enclose virus, bacteria, radioactivity, environmental pollution, dietary, etc., and host factors include heredity, gender, race, and age.
In the effort to identify the genetic causes of immune mediated diseases, the genetic complexity underlying the abnormal activity of the body's immune system has been demonstrated; in addition this, shared risk factors involved in the development of these entities has been described. These studies have also provided valuable information to identify potential therapeutic targets.
The objective of this special issue is to provide an updated overview of the genetic, genomic, and epigenetic factors, as well as the genetic-environmental interactions involved in immune-mediated diseases and the identification of potential new therapeutic targets.
The topic aims to cover the following themes:
1. Epidemiological studies and ethnic incidences of immune-mediated diseases such as arthritis, erythematosus lupus, and cancer.
2. Association studies focused on the analysis of polymorphisms and mutations in the nuclear and mitochondrial genome.
3. Experimental data contributing to the understanding of the molecular mechanisms involved in the development of these diseases.
4. Studies employing public databases and novel bioinformatic tools to increase our knowledge of their genetic causes.
5. Gene-gene and gene-environment interaction analysis.
6. Articles describing the shared genetic background of immune-mediated diseases.
Original research contributions, meta-analyses, and review articles that increase our understanding of the causes of immune diseases are also welcome.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.