About this Research Topic
In this Research Topic, we invite contributions that both enhance our understanding of the pathophysiology of myocardial IR injury and that present the new therapeutic strategies that will protect the myocardium and decrease the morbi-mortality in patients by learning from past failures.
Reviews and original manuscript contributions may give new clues for the development of car-dioprotective strategies that will succeed in clinical setting. Papers may focus on the description of IR-induced cell death mechanisms including newly described mechanisms. Also they will focus on the development of cardioprotective strategies targeting these cascades including me-chanical, pharmacological, gene and cellular therapies, considering also the therapeutic time window appropriate for clinical applications. Approaches based on combination of existing therapies or considering big data technology may be considered. Finally, studies taken into account co-morbidities such as diabetes will be welcomed. Reports may concern basic science, preclinical, translational and clinical studies from bench to bed side and vice versa to increase the chance to translate.
Potential topics include:
1) An update or novel knowledge on myocardial ischemia-reperfusion (IR) injury from basic research, pre-clinical, as well as clinical research including also big data relevant for the understanding of the disease. Involvement of the microcirculation.
2) Description of cell death mechanisms and their regulatory pathways involved in myocardial ischemia-reperfusion (IR) injury.
3) New pharmacological tools or combination of drugs with pleiotropic cardioprotective effects.
4) New therapeutic strategies: gene therapy, gene editing, cell therapy and their extracellular-derived vesicles targeting cell death in IR injury.
5) Pre-clinical or clinical studies evaluating mechanisms and therapeutic strategies targeting IR-induced cell death in diabetes models
6) Devices improving survival after cardiac transplantation.
Keywords: cell death, ischemia-reperfusion injury, myocardium, cardioprotection, diabetes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.