About this Research Topic
Membrane contact sites (MCS) have gained a lot of attention throughout the past decade. They have been recognized as important players facilitating inter-organelle communication. Especially regarding cellular lipid traffic MCS are regarded as efficient alternatives to vesicular trafficking. Yeast has proved as a useful model organism in identifying molecular structures and mechanisms of MCS with good levels of evolutionary conservation to higher eukaryotes.
In this Research Topic we want to focus on functional aspects regulated through membrane contact sites. These functional aspects may include inter-organelle communication, organelle structure, organelle inheritance and biogenesis, lipid and protein traffic but also extend to cellular processes such as autophagy, membrane stress responses, cell death and ageing. Our knowledge on MCS has increased incredibly throughout the past years. And scientists increasingly recognize the importance of MCS as general subcellular organization forms dynamically regulating multi-organelle-processes allowing for functional plasticity.
We are keen on highlighting recent advances from the field of MCS research and creating novel functional connections to the beforementioned research fields. Our goal is thus to provoke thinking from new angles and prospectively interconnect those research fields.
We are interested in publishing Original Research, any type of Review, as well as Perspectives, Opinion or Commentaries focusing on either of the following topics:
• Structure, composition and dynamic regulation of MCS
• Structural traits of molecular tethers and lipid transfer activities
• Implication of MCS and lipids in cell death and ageing
• The role of MCS and lipid metabolism in autophagy
• Dynamic regulation of MCS plasticity
• MCSs as coordinators of lipid metabolism between organelles
• Roles of MCSs in membrane stress responses
• MCSs in organelle biogenesis, inheritance and the regulation of cell structure
• Influence of MCSs on the formation of membrane domains and lipid signaling
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.