Research Topic

Endophytes and Their Biotechnological Applications

About this Research Topic

Endophytes are microorganisms found naturally inhabiting the tissues of the host plants, without causing any symptoms. Their association with their host plants are generally mutualistic symbiotic, with host plants benefiting in terms of improved growth and greater tolerance to biotic and abiotic stress, and ...

Endophytes are microorganisms found naturally inhabiting the tissues of the host plants, without causing any symptoms. Their association with their host plants are generally mutualistic symbiotic, with host plants benefiting in terms of improved growth and greater tolerance to biotic and abiotic stress, and endophytes deriving shared nutrients. In recent years, endophytes have been increasingly explored for the plethora of beneficial compounds that they produced, used for various applications such as for agricultural, biomedicinal, bio-industrial, biopharmaceutical, biocatalytic, bioenergy, and in bioremediation. This is attributed to the nature of the compounds produced, which have been found to have properties that are antimicrobial, antioxidant, antitumor, as well as the ability to biodegrade and biotransform compounds into valuable compounds. In addition, the enzymes and pigments produced are valuable as well, with applications extending to bioindustries and food applications. There is therefore tremendous potential in sourcing endophytes for various biotechnological applications.


Understanding of endophytes as resources is pivotal in discovering novel compounds and expanding their applications to various industries. The progress in endophyte research has led to many new species discovered from various host plants and their bioactivities realized with assays. In recent years, the development of new methods in biotechnologies allowed for more endophytes to be identified via molecular typing, and their bioactive compounds characterized and elucidated for further exploration. This is achieved via bioassays, HPLC, and metabolomics analysis. Biotechnological means also allow for improvements, enhancements, and up-scaling of production, to meet the growing demand for innovative use of compounds from endophytes. Bioprospecting compounds and metabolites from endophytes is evidently a more sustainable approach as well, as endophytes are renewable resources and amenable to translational technologies. The integration of biotechnological approaches has expounded the discovery of endophytes for more significant applications. This project will consolidate research and advances in endophyte from multi-disciplinary approaches for biotechnological applications.


The aim of this Research Topic is to cover multidisciplinary research on any aspect of sourcing endophytes for biotechnological applications. This includes reports on the biodiversity of endophytes and the biotechnological advances in researches related to developing endophytes for biotechnological applications.
We welcome Original Research, Methods, Review, Mini Review, and Brief Research Reports pertaining to how endophytes or their bio-products/derivatives are explored for:

• biocatalysis and biotransformation
• agriculture, biocontrol, bio fungicide, biopesticide
• bio industries, industrial processes
• food, fermentation, pigments
• biomedicine, biopharmaceutical
• molecular advances, genetic engineering, protein engineering
• biochemistry and lead compound research
• all -omics technology (metabolomics, genomics, proteomics)


Keywords: Bioactive compounds, Biotechnology, Endophytes


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

06 January 2021 Manuscript
05 February 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

06 January 2021 Manuscript
05 February 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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