Research Topic

Emerging Proteins and Polypeptides Expressed by “Non-Coding RNAs”

About this Research Topic

Non-coding RNAs (ncRNAs) are defined as RNA molecules that do not encode proteins. However, emerging evidence has proven that many ncRNAs, including lncRNAs and cirRNAs, can encode and express proteins/polypeptides with more than 50 amino acids. Researches also demonstrated that these proteins/polypeptides play essential roles with diverse biological functions, including tumor energy metabolism, cell development, muscle contraction and DNA repair. Thus, identification and characterization of the unrecognized proteins/polypeptides encoded by ncRNAs may contribute to a better understanding of biology and human health.

Following the development of deep ribosome sequencing and mass spectrometry, recent studies have identified that a subset of ncRNAs can encode proteins/polypeptides consist of more than 50 amino acids. These proteins/polypeptides may form a treasury box containing novel functional molecules related to human physiology and pathology. This research topic focuses on the identification and functional characterization of the proteins/polypeptides (with ≥ 50 AAs) encoded by ncRNAs, aiming to understand the mystery of non-coding gene expression better, serving as a forum for the discussion of gene annotation and the discovery of novel physiological and pathological molecules.

Research articles and Reviews in multiple disciplines of proteins/polypeptides (with ≥ 50 AAs) encoded by ncRNA. The scope includes but is not limited to the following subjects:
• Novel methods, tools, strategies of detecting the new or existed proteins/polypeptides encoded by ncRNAs.
• New software/database/pipelines for identifying the new or existing proteins/polypeptides encoded by ncRNAs.
• Deciphering the targets and functions of the proteins/polypeptides encoded by ncRNAs.
• Deciphering the mechanisms and signalling pathways involved by the proteins/polypeptides encoded by ncRNAs.
• Decoding the relationships between coding genes and “ncRNAs”.
• Studying the proteins/polypeptides encoded by ncRNAs as biomarkers and drug targets.


Keywords: Non-coding RNAs, polypepetides, proteins, peptides


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Non-coding RNAs (ncRNAs) are defined as RNA molecules that do not encode proteins. However, emerging evidence has proven that many ncRNAs, including lncRNAs and cirRNAs, can encode and express proteins/polypeptides with more than 50 amino acids. Researches also demonstrated that these proteins/polypeptides play essential roles with diverse biological functions, including tumor energy metabolism, cell development, muscle contraction and DNA repair. Thus, identification and characterization of the unrecognized proteins/polypeptides encoded by ncRNAs may contribute to a better understanding of biology and human health.

Following the development of deep ribosome sequencing and mass spectrometry, recent studies have identified that a subset of ncRNAs can encode proteins/polypeptides consist of more than 50 amino acids. These proteins/polypeptides may form a treasury box containing novel functional molecules related to human physiology and pathology. This research topic focuses on the identification and functional characterization of the proteins/polypeptides (with ≥ 50 AAs) encoded by ncRNAs, aiming to understand the mystery of non-coding gene expression better, serving as a forum for the discussion of gene annotation and the discovery of novel physiological and pathological molecules.

Research articles and Reviews in multiple disciplines of proteins/polypeptides (with ≥ 50 AAs) encoded by ncRNA. The scope includes but is not limited to the following subjects:
• Novel methods, tools, strategies of detecting the new or existed proteins/polypeptides encoded by ncRNAs.
• New software/database/pipelines for identifying the new or existing proteins/polypeptides encoded by ncRNAs.
• Deciphering the targets and functions of the proteins/polypeptides encoded by ncRNAs.
• Deciphering the mechanisms and signalling pathways involved by the proteins/polypeptides encoded by ncRNAs.
• Decoding the relationships between coding genes and “ncRNAs”.
• Studying the proteins/polypeptides encoded by ncRNAs as biomarkers and drug targets.


Keywords: Non-coding RNAs, polypepetides, proteins, peptides


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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