About this Research Topic
Recent advances in animal systems have suggested that assembly of SGs is a two-step process, initiated with the formation of a dense and stable SG core, followed by the accumulation of proteins containing low-complexity regions (LCRs) and intrinsically disordered prion-like domains (PrLDs) into a peripheral shell, via a process involving liquid-liquid phase separation (LLP). It has been described that the central core of SGs typically contains components of the translational machinery, including mRNAs, eukaryotic translation factors, poly-A binding proteins (PABP) and the recruitment of 40S ribosomal proteins. In addition, proteins with different regulatory functions were shown to be localized into SG complexes, suggesting that it might be part of the mechanism that regulates protein stability and function, as well as moderating signaling cascades inside the cell. There is still more left to understand in the dynamics and functionality of SGs. What is the mechanism of recruitment? How the assembly and disassembly is being triggered? What are the components involved in increased stress tolerance?
This Research Topic aims to provide a framework to address the relevant queries in relation to organization, dynamics, development, and functionality of SGs. We invite contributions that fall under, but are not limited to the following topics:
• Mechanism of stress granule formation
• Role of SGs in stress signaling or tolerance
• Relation of SGs with other RNA foci
• SG composition
• SG involvement in regulation of protein stability
• Autophagy-related cytosolic foci
Keywords: mRNA stability, stress signaling, cell survival, plant stress granules
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