Natural Killer (NK) cells are innate immune cells that are key effectors in immune responses against cancer and infection. They also play important roles in placentation and reproduction. Recent studies have unravelled some of the factors and the events that control NK cell ontogeny and regulate NK cell fate. In particular, the use of knockout mice has enabled the discovery of key transcription factors essential for NK cell development and function. Yet, unwrapping the downstream targets of these transcription factors and their influence on NK cells remains a challenge. Gaining insight in the regulation of NK cell development and function in mice and in humans will provide a better comprehension of the mechanisms regulating NK cells and will unveil strategies for targeted therapies. This Frontiers Research Topic aims to provide an overview on how transcription factors regulate NK cell development, maturation and functions. The presentation of ongoing original works as well as data, review articles, methods articles and opinions around the topic are encouraged.

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