About this Research Topic
With the development of various -omics techniques, growing evidence has indicated that the microbiota that resides in the gut are involved in modulating brain development and regulating behavioral phenotypes via the gut-brain axis. A growing interest has developed focusing on the potential effects of the gut-brain axis in neurodevelopmental disorders. Many human and animal studies have found that gut microbiota plays a vital role in the bidirectional communications between the gut and brain. Various gut-brain disorders, such as depression, autism, anxiety, Alzheimer’s disease, irritable bowel syndrome, and so on, are correlated with the dysbiosis of gut microbiota and altered metabolic activities obviously. Studies have found many novel non-invasive diagnostic biomarkers or models for psychiatric disorders targeting on the gut microbiota and revealed the possible mechanisms of gut-brain disorders through the microbiota-gut-brain axis. Restoring the balance of the microbiota-gut-brain axis offers promising beneficial therapeutic effects. Psychobiotics, including prebiotics, probiotics, and other types of products that may influence gut microbiome, can be used as a class of novel psychotropics to treat gut-brain disorders via microbiota-gut-brain axis modulation.
The microbiota-gut-brain axis has attracted great interest and became a hot international research spot. However, previous studies mostly focused on bacterial flora in various gut-brain disorders, while the gut fungal and viral flora were rarely investigated. In addition, multi-omics might help decipher the roles and mechanisms of gut microbiota on microbiota-gut-brain axis more deeply. In fact, many novel key functional bacteria could not be cultured with present conditions, while culturomics might provide new solutions to culture these new bacteria. Moreover, the roles and mechanisms of psychobiotics in treatment of various gut-brain disorders remain unclear.
The aim of this Research Topic is to publish Original Research and Review articles that may provide new insight into:
• Human and animal studies on the gut microbiota and gut-brain disorders, not only focused on bacterial microbiota but also fungal and viral microbiota.
• Multi-omics researches on the mechanisms of gut-brain disorders targeting the microbiota-gut-brain axis in the animal models.
• Novel key functional bacteria exploring with culturomics that associated with gut-brain disorders.
• The roles and mechanisms of psychobiotics on gut-brain disorders in human and animal studies.
• The effect of gut microbiota on local and systemic immune system development and function
Keywords: Gut Microbiota, Depression, Gut-Brain Axis, Alzheimer’s Disease, Psychobiotics
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