About this Research Topic
The genetic compositions of individuals are largely stable over lifespan, however, the age of onset of neuropsychiatric diseases vary between individuals and diseases. In addition, non-genetic risk factors for neuropsychiatric diseases are constantly changing during lifespan. How genetic variants exert their effect on the development of neuropsychiatric disease in terms of timing is a hot research topic in the field of neurogenomics. Questions, such as “Do risk conferring genetic variants manifest their effect at specific time or influence other non-genetic risk factors for neuropsychiatric diseases throughout lifespan?” and “Are treatment response trajectories influenced by the genetic composition of patients?” has not been thoroughly studied. A gain of knowledge will help us improving disease prognosis and personalized treatment. Thus, this Research Topic focuses on studies of genetic effect on the development, progression, and treatment response of neuropsychiatric diseases.
We are aiming to collect studies integrating genomics with traditional longitudinal studies focusing on changes into brain structure or function and the development or treatment of disease. Topics of interest include the following:
• Studies of genetic impact on the age of onset of neuropsychiatric diseases.
• Studies of genetic influence on the changes of biomarkers for neuropsychiatric diseases.
• Studies of genetic impact on the treatment response trajectories for neuropsychiatric diseases.
Articles in the form of Original Research, Reviews and Perspectives related to the above topics will be considered for this Research Topic.
Keywords: Genomics, Brain changes, Neuropsychiatry, Longitudinal analysis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.