Research Topic

Genetic and Environmental Influences on the Stressed Brain: A Neuroimaging Perspective

About this Research Topic

Nowadays, more and more individuals experience stressful life events in their daily life, and a small proportion of them may develop stress-related disorders, including acute stress disorder, posttraumatic stress disorder, and adjustment disorder.

The relationship between psychosocial stress and stress-related disorders is affected by the individual’s biological vulnerability (i.e., genetics and gender), as well as by the personal and environmental factors, including childhood trauma, personality characteristics, prior psychiatric history, social support, and coping styles.

However, the roles of these biological, personal, and environmental factors, especially their interplay on stress-related disorders have not been fully understood. Neuroimaging techniques provide noninvasive, precise, and quantitative means to assess the influences of these factors on the stressed brain, improving our understanding of the underlying neuro-mechanisms of the development of stress-related disorders.

This Research Topic welcomes contributions to the investigation of the influences of biological, personal, and environmental factors and their interactive effects on the stressed brain from the neuroimaging perspective.

The Sub-themes of this Research Topic include but are not limited to the following:
• Functional and structural MRI, PET studies of the influences of stress-related genes (i.e., CRHR1, CRHBP, FKBP5, and COMT) on the normal and stressed brain in human and/or animal models. These studies should focus on the gene association and may use weighted genetic risk scores.
• Research to identify and elucidate the neuro-mechanisms by which the gender, personal and environmental factors (childhood trauma, social support, etc.) exerting their effects on the normal and stressed brain.
• Research clarifying how the interactions of genetic and personal/environmental risk factors contribute to the development of stress-related disorders.


Keywords: Stress-related Disorders, Genetic and Environmental Influences, Neuroimaging, fMRI, PTSD


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Nowadays, more and more individuals experience stressful life events in their daily life, and a small proportion of them may develop stress-related disorders, including acute stress disorder, posttraumatic stress disorder, and adjustment disorder.

The relationship between psychosocial stress and stress-related disorders is affected by the individual’s biological vulnerability (i.e., genetics and gender), as well as by the personal and environmental factors, including childhood trauma, personality characteristics, prior psychiatric history, social support, and coping styles.

However, the roles of these biological, personal, and environmental factors, especially their interplay on stress-related disorders have not been fully understood. Neuroimaging techniques provide noninvasive, precise, and quantitative means to assess the influences of these factors on the stressed brain, improving our understanding of the underlying neuro-mechanisms of the development of stress-related disorders.

This Research Topic welcomes contributions to the investigation of the influences of biological, personal, and environmental factors and their interactive effects on the stressed brain from the neuroimaging perspective.

The Sub-themes of this Research Topic include but are not limited to the following:
• Functional and structural MRI, PET studies of the influences of stress-related genes (i.e., CRHR1, CRHBP, FKBP5, and COMT) on the normal and stressed brain in human and/or animal models. These studies should focus on the gene association and may use weighted genetic risk scores.
• Research to identify and elucidate the neuro-mechanisms by which the gender, personal and environmental factors (childhood trauma, social support, etc.) exerting their effects on the normal and stressed brain.
• Research clarifying how the interactions of genetic and personal/environmental risk factors contribute to the development of stress-related disorders.


Keywords: Stress-related Disorders, Genetic and Environmental Influences, Neuroimaging, fMRI, PTSD


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

10 October 2020 Abstract
07 February 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

10 October 2020 Abstract
07 February 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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