About this Research Topic
ROS have been implicated in many aspects of the immune response to pathogens. They have been proposed to be the common determinant of the inflammasome activation critical in the inflammatory process which is determinant for an efficient immune response. ROS are also essential for pathogens killing by phagocytic cells as illustrated by chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase characterized by recurrent and severe bacterial and fungal infections. Moreover, ROS are also required for full activation of lymphocytes as well as for the regulation of immunity mediated by the myeloid-derived suppressor cells (MDSC).
This Research Topic aims to give an update of the contribution of Reactive Oxygen Species in immunity, focusing on different aspects of the immune response as well as immune system pathologies. We welcome the submission of Original Research articles, Reviews, Mini-Reviews, to cover the following topics:
1. ROS and immune cell development and differentiation
2. ROS and immune cell activation, maturation and effector function
3. ROS in inflammation and protective immunity
4. ROS and immunopathology, biomarker and diagnostic
5. Redox modulations as therapeutic intervention
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.