About this Research Topic
Emerging evidence has shown that several types of additional information beyond SNPs can assist GWAS to identify causal mutations and/or increase the accuracy of GP: 1) using functional annotation of SNPs, such as the gene regulation information; 2) conducting GWAS and/or GP for more than one trait which leverages the information of pleiotropy and 3) conducting GWAS and/or GP in multiple breeds which adds power in finding and utilizing variants segregating in multiple breeds. Therefore, we proposed the topic of “Multi-layered genome-wide association/prediction in livestock and animal species” to examine to what extent the additional information beyond SNPs described above can improve GWAS and GP.
We welcome manuscript formats including Mini-Reviews, full-length Reviews, and Original Research. Our topic welcomes, but is not necessarily limited to:
· GWAS with functional information from the transcriptome, epigenome, metabolome, or any functional annotation of the genome
· GWAS with more than one trait, either fitting multiple traits in one model or using meta-analysis to combine results from single-trait studies
· GWAS with more than one breed, either using multi-breed regression or using meta-analysis to combine results from single-breed analyses
· Genomic prediction with functional information of the genome
· Genomic prediction with multiple traits, either using multi-variable training/prediction or using post hoc methods to combine results from single-trait analyses
· Genomic prediction with multiple breeds, either using multiple breeds in the training/prediction or using post hoc methods to combine results from single-breed analyses
· GWAS and/or genomic prediction that cover more than one of above-described areas, e.g., GWAS + multi-omics + multi-breeds
Keywords: GWAS, genomic prediction, multi-omics, multi-trait, multi-breed
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.