About this Research Topic
Everything occurs in circular sequences: revolution, change, adaptation to change, acceptance of the new standard, organizing the new establishment, resistance to further change, revolution, and the cycle begins again. In surgery, this cycle had been occurring about every 100 years, but recently there has been a perceptible acceleration of this cycle. New scientific advancements could privilege thoracic surgeons in expanding an existing skill set or could achieve thoracic surgeons to perform new procedures outside the traditional boundaries of thoracic surgery. Nonetheless, science is accelerating quicker than ever, and we are on the edge of another revolution. This is a time, in the history of thoracic surgery when the truthfully revolutionary transformation is occurring at a rate never seen before. While it is a historical fact that each generation of physicians significantly exceeds the accomplishments of the previous generation, the magnitude of actual changes is extraordinary. The surgeon of the future will need to absorb a broader range of the modern sciences, quicker than ever before. Although the exact sciences are perceived by most people as far away from the more experimental surgery, indeed the modern surgery has its foundations in them.
Basic sciences could play a significant role in lung cancer surgery. It is the rapid development of physics and biology, underpinned by mathematics, which has made medical advances possible: the development of the microscope; the discovery and use of radiation for diagnosis and therapy; the explosion of clinical laboratory investigations for diagnosis and prognosis. Therefore, every thoracic surgeon should have a basic understanding of the underlying sciences to obtain a three-dimensional point of view of surgery, as not just a mechanical series of movements but also as a precision science. Since it is from science, or how things work, that technology, or how to get things to work, emerges. This Research Topic would like to make the bold effort of inquiring the sciences behind Thoracic Surgery by involving biologist and medical doctors and creating a sharp dialogue between all these disciplines. All that in the conviction that mutual exchanges can improve knowledge in Thoracic Surgery field and promote the progress.
We would like contributors to address the following themes:
• Introduction to Lung Cancer Biology
• Introduction to Lung Cancer Epidemiology
• Cellular Signalling Pathways
• Lung Cancer Cell Proliferation and Death
• Nodal and Systemic Metastases
• Imaging in Lung Cancer Oncology
• Molecular and Cellular Basis of Radiotherapy for Lung Cancer
• The Incorporation of Fundamental Research in Thoracic Surgery
• Pharmacology of Anticancer Drugs
• The Immune System and Immunotherapy
Keywords: Lung cancer, Thoracic Surgery, Biology, Basic Research, Methodology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.