Research Topic

Phage Biology and Phage Therapy

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Bacteriophages are the most abundant biological entities on earth. They widely exist in nature and significantly affect the physiological and ecological state of bacteria in many ways, such as regulating the microbiota community or conferring antibiotic resistance or virulence to bacteria. However, the number ...

Bacteriophages are the most abundant biological entities on earth. They widely exist in nature and significantly affect the physiological and ecological state of bacteria in many ways, such as regulating the microbiota community or conferring antibiotic resistance or virulence to bacteria. However, the number of phages that have been isolated and identified is still relatively limited, and a large number of phages in the natural environment have not been studied yet, for example, phages in the human intestine and oral cavity.
Phage therapy has already been implemented successfully against some infections, such as burn wound infection, urinary tract infection, and so on, and phages have also been applied to control microbiome dysbiosis, such as during Enterococcus faecalis-associated alcoholic liver disease. Progress in the identification and understanding of phage biology is essential in working towards the end goal of phage therapy: using bacteriophages to eradicate of pathogenic bacteria, or to manipulate bacterial communities for human health benefits.
This Research Topic will accept Original Research, Opinions, Perspectives and Reviews on phage biology and phage therapy in the context of human infection diseases and human microbiome, in particular:
• Phages with improved efficacy in controlling infectious diseases
• Phage therapy strategies
• Phages isolated from the human body including from the oral cavity, gut and skin
• The impact or application of phages on regulating bacterial communities in humans


Keywords: bacteriophage, phage therapy, microbiome, infection disease


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