About this Research Topic
Sepsis, a life-threatening syndrome characterized by organ failure after infection, is the most common cause of death in hospitalized patients. Sepsis treatment is generally supportive in nature, involving the administration of intravenous fluids, vasoactive substances and antibiotics to eliminate the pathogen. No drugs have been explicitly approved for sepsis treatment, and clinical trials of potential therapies have failed - suggesting that new approaches are needed. Covid-19 - induced sepsis is a classic example. Therefore, it is crucial to find a new strategy to investigate further the pathogenesis and pathophysiological process for sepsis treatment and new drugs.
The pathophysiological process of sepsis involves both inflammation and immunity and the proliferation of pathogens. Previous studies have paid more attention to the excessive inflammatory response but ignored the disorders of the body's immune system, such as immunosuppression, and attention is paid to the proliferation of anti-pathogen. Still, the mobilization of anti-infection ability is neglected. This topic intends to provide outline sepsis in the field of basic and clinical research but is no longer a simple study of the body's inflammatory or pathogens proliferation. Furthermore, based on the body's immune response to comprehensively consider the new strategy of regulating the body's resistant ability. The purpose is to provide a new research field, and the angle of view lay a foundation for the further study of sepsis. Therefore, this topic is intended to include studies based on sepsis such as the pathophysiological mechanism, clinical studies such as the evaluation of the current situation of clinical use of existing drugs and strategies, and research on a new approach to highlight sepsis based on the signal transduction pathways involved in the occurrence of sepsis.
In this Research Topic, we welcome original research articles, reviews, mini-reviews, opinion, perspective, and systematic review, including but not limited to the following themes:
• Investigation on the pathophysiological mechanism and new targets of sepsis: Investigation on the pathophysiological mechanism and signal transduction pathway of sepsis, and discover new potential drug targets.
• Current status of sepsis treatment and drugs evaluation: Evaluation of existing medications for sepsis, such as hormones.
• New drug studies for sepsis: Based on new drug studies for sepsis, such as studies of artemisinin and its derivatives to intervene in sepsis immune disorders, and drug studies for NETs.
• Investigation of other treatments against sepsis: Investigation on new hemodialyzer to remove endotoxins and excess pro-inflammatory cytokines in the blood, the use of anti-infective drugs to stop the proliferation of pathogens (bacteria and viruses) during sepsis, and the development of new anti-infection agents.
Keywords: Sepsis, pathogenesis, signal transduction pathway, treatment, therapeutic strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.