Research Topic

Engineering Signal Sensors Based on Reprogrammed CRISPR Technologies

About this Research Topic

The ability to detect biological signals has a great impact on human health and medicine. Artificial biological signal sensors usually include a gene network composed of basic modules that can sense, integrate and process specific biological signals. However, there are still some technical problems in the ...

The ability to detect biological signals has a great impact on human health and medicine. Artificial biological signal sensors usually include a gene network composed of basic modules that can sense, integrate and process specific biological signals. However, there are still some technical problems in the design and assembly of signal sensors.

The discovery of the CRISPR systems has enriched the application of biotechnology. As a type of robust and simple toolbox, the CRISPR system has greatly promoted the development of signal sensors both in vitro and in vivo. The reconstruction of signal sensor based on CRISPR technologies can further promote the development of disease diagnosis and gene therapy.

Improving the regulatory ability and programmability of CRISPR systems will provide a useful toolbox for building novel types of cellular signal sensors. Because the CRISPR system contains two elements, Cas protein and sgRNA, two different corresponding strategies will be developed for constructing CRISPR signal sensors. It is possible to respond to biological signals by re-engineering different domains of Cas proteins. The reprogrammed CRISPR signal sensors, based on sgRNA reconstruction, will also provide an easy implementation and versatile way to sense biological signals. The CRISPR sensors that sense the changes of proteins and RNAs will have various medical applications, including disease diagnosis and treatment.

The aim of this Research Topic is to develop signal sensors based on reprogrammed CRISPR technologies. Areas to be covered in this Research Topic may include, but are not limited to:

• CRISPR systems for sensing small molecule drugs
• CRISPR systems for sensing intracellular proteins
• CRISPR systems for sensing cellular non-coding RNAs
• CRISPR systems for sensing viral nucleic acids
• CRISPR molecular platforms for diagnosing viral infections and other genetic diseases
• CRISPR signal sensors for treating complex diseases such as malignant tumors


Keywords: CRISPR, sgRNA, signal sensor, disease diagnosis, disease treatment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

07 March 2021 Manuscript
30 April 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

07 March 2021 Manuscript
30 April 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..