Over the last several decades, hydrogen sulfide (H
2S) has been reported to exert multiple physiological functions in mammal systems. Mounting evidence indicates the physiological significance of H
2S because of its role in a wide range of physiological and pathological activities in mammal systems, especially in the cardiovascular system, central nervous system, and other biological systems. As such, H
2S has gained recognition as the third gaseous signaling molecule along with nitric oxide (NO) and carbon monoxide (CO). Endogenous H
2S in mammal systems is mainly generated by either enzymatic or non-enzymatic pathways. The enzymatic process is dependent on the actions of cystathione ß-synthase (CBS), cystathione ?-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST). Our previous Research Topic,
Hydrogen sulfide: Physiology, Pharmacology and Toxicology (Volume 1) launched in 2016, has been a highlight for the readership of the journal Frontiers in Pharmacology and has gained attention in the field. However, many aspects of H
2S are still not yet fully understood and often controversial. As this is a recent and rapidly evolving field, an overview of the obtained results and the future perspectives is highly desirable. The complicated biological effects, long term toxic accumulation and lack of system specific effects continuously challenges scientists to develop H
2S-releasing drugs.
The aim of the Volume 2 of this Research Topic is to highlight recent advances in our understanding of the physiological and pharmacological functions of H
2S. We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the biogenesis, metabolism and biological functions of H
2S. Submission of pharmacological functions/toxic effects and other related sulfide containing compounds are also welcome. Potential topics include, but are not limited to:
•Biological function in the new compounds releasing H
2S, polysulfide and SO
2 •New methods for detection of endogenous and exogenous H
2S
•Advances in biosynthesis and metabolism of H
2S.
•Current understanding about protein sulfhydration
•Signaling mechanisms underlying the biological functions of H
2S
•Prospect of sulfide-containing nature products and H
2S synthesis inhibitors as therapeutic drugs