Research Topic

New Advances in Epilepsy and Headache

About this Research Topic

Epilepsy and Migraine, the most common primary headache, are among the most frequent and disabling neurological conditions. They are frequently described as highly comorbid conditions. The prevalence of migraine in patients with epilepsy is at least twice that of the normal population, while the prevalence of ...

Epilepsy and Migraine, the most common primary headache, are among the most frequent and disabling neurological conditions. They are frequently described as highly comorbid conditions. The prevalence of migraine in patients with epilepsy is at least twice that of the normal population, while the prevalence of epilepsy in patients with migraine is about 6% compared to 1% of general population.
Both disorders have common clinical features and they probably share a common physiopathology, involving the balance between cortical excitatory and inhibitory factors, and a genetic predisposition (same genes can cause both conditions). Moreover, to support this hypothesis, several antiepileptic drugs are used with benefit to treat patients with migraine as well as with epilepsy. In summary, some authors consider migraine and epilepsy as two sides of the same coin.

We are pleased to welcome submissions on biochemical, molecular, and genetic aspects underlying the pathobiology of epilepsy and primary headaches. We would also welcome submissions about the epidemiological aspects, prevention strategies, risk factors and recent advances in the treatment of epilepsy and headache. We will give great consideration and special attention to individualized approaches, precision medicine studies, genomic studies through whole-exome sequencing or whole-genome sequencing, and to transcriptomic and epigenetic research.

Submissions on the following themes are strongly encouraged:
• neuropsychological functions in people with epilepsy or migraine
• whole-exome and whole-genome sequencing studies
• transcriptomic and epigenetic research
• epidemiological investigations and comorbidity studies about epilepsy and migraine
• prevention strategies and risk factors about epilepsy and headache
• Recent advances in the therapeutic approach to headache and epilepsy

We would like to acknowledge that Dr. Luigi Vetri, University of Palermo, Italy , has acted as a coordinator and has contributed to the preparation of the proposal for this Research Topic.


Keywords: epilepsy, migraine, comorbidity, epidemiology, therapeutic approach, transcriptomic, epigenetic, neuropsychological functions


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Submission Deadlines

13 March 2021 Manuscript
12 April 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

13 March 2021 Manuscript
12 April 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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