About this Research Topic
In this Research Topic, we aim to bring together current knowledge and to highlight recent advances in the field of immunology of human type 1 diabetes, as well as discoveries made in animal models that inform our understanding of this complex immunological disease. In addition, we will focus on new discoveries and understanding that may have impact on development of immune therapy, both for prevention as well as treatment of established type 1 diabetes.
We welcome Original Research, Mini Review, Perspective, Opinion articles focusing on, but not limited to, the following themes:
• recent advances in pathology that may include research in: insulitis, measurements of beta cell mass (including beta cell heterogeneity), and evidence of viral involvement in pathogenesis;
• advances in the roles of B cell in immunopathology of type 1 diabetes, including their role in the thymus and discussion relating to new single cell analysis;
• new research and discussion relating to single cell analysis and the potential for identification of new disease modifiers;
• new research on T cells;
• environmental influences focusing on gut bacteria linking to innate immunity and including innate immune cells such as innate lymphoid cells and innate immune molecules;
• pathways to beta cell death, including the role of free radicals and other mechanisms;
• common mechanisms and comparisons with other autoimmune diseases.
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Keywords: Type 1 Diabetes, T cells, B cells, Insulin, Immune therapy, Single cell analysis, Innate immune cells, Society affiliation RT
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.