Transcriptional Regulation in Metabolism and Immunology

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authors

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Editorial

02 February 2022

Editorial: Transcriptional Regulation in Metabolism and Immunology

Chunjie Jiang

,

Shibiao Wan

,

Peng Hu

,

Yongsheng Li

and

Shengli Li

1,789 views

1 citations

Editors

5

University of Texas MD Anderson Cancer Center

School of Medicine, Shanghai Jiao Tong University

University of Nebraska Medical Center

Shanghai Ocean University

Yongsheng Kevin Li

Hainan Medical University

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The regulation of transcription, the conversion of DNA to RNA, is a vital process in all living organisms to orchestrate gene activity. Transcription factors (TFs) are the important factors to orchestrate transcription by binding to specific DNA sequences to activate and/or repress wide repertoires of downstream target genes that control a wide variety of biological processes, including metabolic and immune systems. A large number of TFs that play critical roles in regulating transcription in the metabolic and immune systems have been investigated and much has been learned about their mechanisms. With the progress of high throughput sequencing and other state-of-the-art technologies, some recent studies have precisely highlighted dysregulated TFs in specific contexts. However, the field still remains in its infancy, with the complexity of gene regulation circuitry limiting our current knowledge and providing formidable barriers to further advancement.

This Research Topic is dedicated to publishing studies revealing the mechanisms of transcriptional regulation in metabolic and/or immune systems based on the data sets from next-generation sequencing and other state-of-the-art technologies, which will shed light on the deeper understanding of the underlying mechanisms.

We welcome the submission of Original Research papers, as well as Review, Research Report or specific comment on recently published articles that are related to this topic.

The regulation of transcription, the conversion of DNA to RNA, is a vital process in all living organisms to orchestrate gene activity. Transcription factors (TFs) are the important factors to orchestrate transcription by binding to specific DNA sequences to activate and/or repress wide repertoires of downstream target genes that control a wide variety of biological processes, including metabolic and immune systems. A large number of TFs that play critical roles in regulating transcription in the metabolic and immune systems have been investigated and much has been learned about their mechanisms. With the progress of high throughput sequencing and other state-of-the-art technologies, some recent studies have precisely highlighted dysregulated TFs in specific contexts. However, the field still remains in its infancy, with the complexity of gene regulation circuitry limiting our current knowledge and providing formidable barriers to further advancement.

This Research Topic is dedicated to publishing studies revealing the mechanisms of transcriptional regulation in metabolic and/or immune systems based on the data sets from next-generation sequencing and other state-of-the-art technologies, which will shed light on the deeper understanding of the underlying mechanisms.

We welcome the submission of Original Research papers, as well as Review, Research Report or specific comment on recently published articles that are related to this topic.

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Editors

University of Texas MD Anderson Cancer Center

School of Medicine, Shanghai Jiao Tong University

University of Nebraska Medical Center

Shanghai Ocean University

Yongsheng Kevin Li

Hainan Medical University

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104,829 Total views

71,610 Article views

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Frontiers in Genetics

Computational Genomics

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Frontiers in Plant Science

Computational Genomics

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Frontiers in Bioengineering and Biotechnology

Computational Genomics

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