About this Research Topic
Orally administered health promoters are critical mediators in enhancing the fish immune system. The growing worldwide interest in reducing synthetic chemical application in aquaculture production has resulted in an overwhelming cumulus of reports describing various enhancers beneficial properties from products with a natural origin. However, to assess the potential promoters expected immunological enhancement capacity, the assays of choice are current and mostly supported on outdated primary descriptive indicators. On the functional side, few studies support their proposed findings evaluating the hypothetical improved targeting tissue-specific capacity suggested or challenging, in vivo, the animals against significant threats.
In this Research Topic, we seek to collect research articles or review manuscripts covering comparative and developmental works on the oral immune enhancement at the cellular or humoral immune level. The use of robust molecular tools accompanied by strategies of analysis devoted to elucidating the mode of action for the tested natural compounds is highly appreciated. By gathering this holistic collection of evidence, we expect to advance the present knowledge and understand beyond the immune effects and the responding immune mechanisms in fish fed with functional feed additives of natural sources under an experimental or fish farm setting.
We welcome the submission of Original Research articles, Reviews, and Mini-Reviews, which cover, but are not limited to, the following topics:
1. Genome-wide and omics approaches linking the functional foods or nutritional programming with improved fish immunological fitness.
2. Germ-free individuals to study the impact of the dietary treatment on the host-microbe interactions at the naive immune status.
3. Strategies based at the protein level, the innate memory, chromatin remodeling, and metabolic reprogramming upon an oral priming event avoiding immune tolerance.
4. Understanding the bidirectional communication between the brain and the intestinal immunity.
5. Effect of the nutritional inputs upon the relationship between the host-microbe and immune response.
6. Artificial intelligence and machine learning techniques as tools for monitoring clinically relevant immune patterns resulting from using oral enhancers and leading to establishing a precision fish farming strategy.
Keywords: Aquaculture, Deep learning, Functional fish feed, Dietary supplements, Epigenetics, Host-pathogen, Immunity, Immunostimulants, Microbiota, Metabolomics, Probiotics, Proteomics, SCFA, Teleosts, Transcriptomics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.