About this Research Topic
The regulatory B cell (Breg) population is widely accepted as an important modulatory component of the immune system, which suppresses inflammation. Breg populations are small under physiological conditions but expand substantially in both human patients and murine models of autoimmune diseases, infection, transplantation and cancer. Almost all B-cell subsets can be induced to form Breg cells. In addition, there are unique Breg-cell subsets such as B10 and Tim-1+ B cells. Immunoregulatory function may be mediated by production of cytokines and/or cell-cell interactions, ensuring suppression of effector cells.
Based on existing research findings, different diseases have distinct Breg phenotypes and various factors play differential suppressive roles based on disease. Moreover, our understanding of the Transcription factors driving Breg differentiation is lacking. Thus, to gain a comprehensive understanding of Breg, the aim of the current Research Topic is to elucidate their phenotypes, differentiation, function, contributions to diseases, and therapeutic potential.
This Research Topic welcomes articles covering, but not limited to, to the following sub-topics:
• Definition and classification of novel regulatory B cell subsets
• Functions of regulatory B cell subsets in health and disease
• Key molecules and transcription factors of regulatory B cell differentiation
• Novel techniques of regulatory B cell subsets, e.g. Single-cell sequencing, Total sequencing, etc
• Bioinformatics tools to study regulatory B cell subsets, differentiation, and function
• Regulatory B cell in diseases, e.g. in tumors, in autoimmune diseases, in infections and in transplants, etc
Keywords: Bregs, IL-10, IL-35, Autoimmune diseases, TGF-beta, Bregs in disease, transcription factors
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