About this Research Topic
Hypoxia and oxidative stress are well established risk factors for tumor progression. Indeed, under hypoxia, cells adapt their metabolism, and increase angiogenesis and erythropoiesis. The hypoxic microenvironment will promote cell proliferation and metastasis, but also control the differentiation of several cell types. In 2019, the Nobel Prize was attributed to Professors Gregg Semenza, Peter Ratcliffe and William Kaelin for their discoveries on the adaptation of the cells to the low partial pressure of oxygen. Such signaling pathways in cancer raise a continuous interest from the scientific community. Moreover, oxidative stress is also a crucial factor for cancer progression and therapy. Production of ROS involve a tight regulation by mitochondria and the antioxidative systems.
During the 8th edition of the International Congress on « Innovative therapeutics for Cancer and Ageing diseases » from October 28 to 30, 2020, more the 200 experts, especially Chinese and French - Academic, Medical, Investors and Industrial players- will discuss about the latest trends in the field of cancer associated diseases.
This special issue of Frontiers in Endocrinology welcomes submissions (original articles, comments, reviews) of all participating labs of this International Congress that are of relevance to endocrinology in relation to cancer. Contribution from other labs are also welcome.
Keywords: hypoxia, oxidative stress, endocrine cancers, ROS, metabolism
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